Evaluating ChatGPT's Performance in Classifying Pneumonia from Chest X-Ray Images

In this study, we evaluate the ability of OpenAI's gpt-4o model to classify chest X-ray images as either NORMAL or PNEUMONIA in a zero-shot setting, without any prior fine-tuning. A balanced test set of 400 images (200 from each class) was used to assess performance across four distinct prompt designs, ranging from minimal instructions to detailed, reasoning-based prompts. The results indicate that concise, feature-focused prompts achieved the highest classification accuracy of 74%, whereas reasoning-oriented prompts resulted in lower performance. These findings highlight that while ChatGPT exhibits emerging potential for medical image interpretation, its diagnostic reliability remains limited. Continued advances in visual reasoning and domain-specific adaptation are required before such models can be safely applied in clinical practice.