Leveraging Open-Source Large Language Models for Clinical Information Extraction in Resource-Constrained Settings

Medical reports contain rich clinical information but are often unstructured and written in domain-specific language, posing challenges for information extraction. While proprietary large language models (LLMs) have shown promise in clinical natural language processing, their lack of transparency and data privacy concerns limit their utility in healthcare. This study therefore evaluates nine open-source generative LLMs on the DRAGON benchmark, which includes 28 clinical information extraction tasks in Dutch. We developed textttllmextractinator, a publicly available framework for information extraction using open-source generative LLMs, and used it to assess model performance in a zero-shot setting. Several 14 billion parameter models, Phi-4-14B, Qwen-2.5-14B, and DeepSeek-R1-14B, achieved competitive results, while the bigger Llama-3.3-70B model achieved slightly higher performance at greater computational cost. Translation to English prior to inference consistently degraded performance, highlighting the need of native-language processing. These findings demonstrate that open-source LLMs, when used with our framework, offer effective, scalable, and privacy-conscious solutions for clinical information extraction in low-resource settings.