Development of MR spectral analysis method robust against static magnetic field inhomogeneity

Purpose:To develop a method that enhances the accuracy of spectral analysis in the presence of static magnetic field B0 inhomogeneity. Methods:The authors proposed a new spectral analysis method utilizing a deep learning model trained on modeled spectra that consistently represent the spectral variations induced by B0 inhomogeneity. These modeled spectra were generated from the B0 map and metabolite ratios of the healthy human brain. The B0 map was divided into a patch size of subregions, and the separately estimated metabolites and baseline components were averaged and then integrated. The quality of the modeled spectra was visually and quantitatively evaluated against the measured spectra. The analysis models were trained using measured, simulated, and modeled spectra. The performance of the proposed method was assessed using mean squared errors (MSEs) of metabolite ratios. The mean absolute percentage errors (MAPEs) of the metabolite ratios were also compared to LCModel when analyzing the phantom spectra acquired under two types of B0 inhomogeneity. Results:The modeled spectra exhibited broadened and narrowed spectral peaks depending on the B0 inhomogeneity and were quantitatively close to the measured spectra. The analysis model trained using measured spectra with modeled spectra improved MSEs by 49.89% compared to that trained using measured spectra alone, and by 26.66% compared to that trained using measured spectra with simulated spectra. The performance improved as the number of modeled spectra increased from 0 to 1,000. This model showed significantly lower MAPEs than LCModel under both types of B0 inhomogeneity. Conclusion:A new spectral analysis-trained deep learning model using the modeled spectra was developed. The results suggest that the proposed method has the potential to improve the accuracy of spectral analysis by increasing the training samples of spectra.