Leveraging Segment Anything Model for Source-Free Domain Adaptation via Dual Feature Guided Auto-Prompting
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Abstract (arXiv)
Source-free domain adaptation (SFDA) for segmentation aims at adapting a model trained in the source domain to perform well in the target domain with only the source model and unlabeled target data. Inspired by the recent success of Segment Anything Model (SAM) which exhibits the generality of segmenting images of various modalities and in different domains given human-annotated prompts like bounding boxes or points, we for the first time explore the potentials of Segment Anything Model for SFDA via automatedly finding an accurate bounding box prompt. We find that the bounding boxes directly generated with existing SFDA approaches are defective due to the domain gap. To tackle this issue, we propose a novel Dual Feature Guided (DFG) auto-prompting approach to search for the box prompt. Specifically, the source model is first trained in a feature aggregation phase, which not only preliminarily adapts the source model to the target domain but also builds a feature distribution well-prepared for box prompt search. In the second phase, based on two feature distribution observations, we gradually expand the box prompt with the guidance of the target model feature and the SAM feature to handle the class-wise clustered target features and the class-wise dispersed target features, respectively. To remove the potentially enlarged false positive regions caused by the over-confident prediction of the target model, the refined pseudo-labels produced by SAM are further postprocessed based on connectivity analysis. Experiments on 3D and 2D datasets indicate that our approach yields superior performance compared to conventional methods. Code is available at https://github.com/xmed-lab/DFG.
Key facts. Cited by 4 papers in the map (data through 14 Oct 2026). Builds on 33 of its 45 references that are in the map. First posted on arXiv 13 May 2025.
Builds on
33 of 45 references.
References · 33
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- 2023Medical SAM Adapter: Adapting Segment Anything Model for Medical Image Segmentationcited by 490
- 2020CHAOS Challenge -- Combined (CT-MR) Healthy Abdominal Organ Segmentationcited by 309
- 2023Customized Segment Anything Model for Medical Image Segmentationcited by 280
- 2023SegGPT: Segmenting Everything In Contextcited by 194
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- 2020Unsupervised Bidirectional Cross-Modality Adaptation via Deeply Synergistic Image and Feature Alignment for Medical Image Segmentationcited by 134
21 more
- 2020MS-Net: Multi-Site Network for Improving Prostate Segmentation with Heterogeneous MRI Datacited by 121
- 2023SAM-Med3D: Towards General-purpose Segmentation Models for Volumetric Medical Imagescited by 107
- 2022Source-Free Domain Adaptation via Distribution Estimationcited by 97
- 2023MA-SAM: Modality-agnostic SAM Adaptation for 3D Medical Image Segmentationcited by 82
- 2021Source-Free Domain Adaptive Fundus Image Segmentation with Denoised Pseudo-Labelingcited by 61
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- 2023Beyond Adapting SAM: Towards End-to-End Ultrasound Image Segmentation via Auto Promptingcited by 40
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- 2022BMD: A General Class-balanced Multicentric Dynamic Prototype Strategy for Source-free Domain Adaptationcited by 39
- 2020Exploiting Chain Rule and Bayes' Theorem to Compare Probability Distributionscited by 22
- 2023FVP: Fourier Visual Prompting for Source-Free Unsupervised Domain Adaptation of Medical Image Segmentationcited by 21
- 2023Source-Free Domain Adaptive Fundus Image Segmentation with Class-Balanced Mean Teachercited by 21
- 2023UPL-SFDA: Uncertainty-aware Pseudo Label Guided Source-Free Domain Adaptation for Medical Image Segmentationcited by 21
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- 2022Rethinking the Role of Pre-Trained Networks in Source-Free Domain Adaptationcited by 13
Built on by
Citing papers per year: 2025: 1; 2026: 3.
4 papers.
- 2025OFL-SAM2: Prompt SAM2 with Online Few-shot Learner for Efficient Medical Image Segmentationcited by 0
- 2026Tell2Adapt: A Unified Framework for Source Free Unsupervised Domain Adaptation via Vision Foundation Modelcited by 0
- 2026DiffuSAM: Diffusion-Based Prompt-Free SAM2 for Few-Shot and Source-Free Medical Image Segmentationcited by 0
- 2026SymmAdapt: Symmetrical Flow Matching for Source-Free Domain Adaptation in Medical Image Segmentationcited by 0
- 2026SymmAdapt: Symmetrical Flow Matching for Source-Free Domain Adaptation in Medical Image Segmentation23 Aug 2026
- 2026DiffuSAM: Diffusion-Based Prompt-Free SAM2 for Few-Shot and Source-Free Medical Image Segmentation27 Apr 2026
- 2026Tell2Adapt: A Unified Framework for Source Free Unsupervised Domain Adaptation via Vision Foundation Model5 Mar 2026
- 2025OFL-SAM2: Prompt SAM2 with Online Few-shot Learner for Efficient Medical Image Segmentation31 Dec 2025