RadSAM: Segmenting 3D radiological images with a 2D promptable model
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Abstract (arXiv)
Medical image segmentation is a crucial and time-consuming task in clinical care, where mask precision is extremely important. The Segment Anything Model (SAM) offers a promising approach, as it provides an interactive interface based on visual prompting and edition to refine an initial segmentation. This model has strong generalization capabilities, does not rely on predefined classes, and adapts to diverse objects; however, it is pre-trained on natural images and lacks the ability to process medical data effectively. In addition, this model is built for 2D images, whereas a whole medical domain is based on 3D images, such as CT and MRI. Recent adaptations of SAM for medical imaging are based on 2D models, thus requiring one prompt per slice to segment 3D objects, making the segmentation process tedious. They also lack important features such as editing. To bridge this gap, we propose RadSAM, a novel method for segmenting 3D objects with a 2D model from a single prompt. In practice, we train a 2D model using noisy masks as initial prompts, in addition to bounding boxes and points. We then use this novel prompt type with an iterative inference pipeline to reconstruct the 3D mask slice-by-slice. We introduce a benchmark to evaluate the model's ability to segment 3D objects in CT images from a single prompt and evaluate the models' out-of-domain transfer and edition capabilities. We demonstrate the effectiveness of our approach against state-of-the-art models on this benchmark using the AMOS abdominal organ segmentation dataset.
Key facts. Cited by 6 papers in the map (data through 14 Oct 2026). Builds on 10 of its 16 references that are in the map. First posted on arXiv 29 Apr 2025.
Builds on
10 of 16 references.
References · 10
- 2020An Image is Worth 16x16 Words: Transformers for Image Recognition at Scalecited by 30,186
- 2016V-Net: Fully Convolutional Neural Networks for Volumetric Medical Image Segmentationcited by 2,292
- 2018UNet++: A Nested U-Net Architecture for Medical Image Segmentationcited by 1,525
- 2021UNETR: Transformers for 3D Medical Image Segmentationcited by 959
- 2021The Medical Segmentation Decathloncited by 628
- 2023Medical SAM Adapter: Adapting Segment Anything Model for Medical Image Segmentationcited by 490
- 2022AMOS: A Large-Scale Abdominal Multi-Organ Benchmark for Versatile Medical Image Segmentationcited by 351
- 2023Segment Anything Model for Medical Image Analysis: an Experimental Studycited by 291
- 2024Segment Anything Model for Medical Image Segmentation: Current Applications and Future Directionscited by 97
- 2023SA-Med2D-20M Dataset: Segment Anything in 2D Medical Imaging with 20 Million maskscited by 55
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Citing papers per year: 2025: 4; 2026: 2.
6 papers.
- 2025CT-Agent: A Multimodal-LLM Agent for 3D CT Radiology Question Answeringcited by 21
- 2025Curia: A Multi-Modal Foundation Model for Radiologycited by 15
- 2025RadImageNet-VQA: A Large-Scale CT and MRI Dataset for Radiologic Visual Question Answeringcited by 6
- 2026Jolia: Concept-Level Vision-Language Alignment for 3D CT Contrastive Learningcited by 4
- 2025RAPS-3D: Efficient interactive segmentation for 3D radiological imagingcited by 0
- 2026Prompt-Guided Interactive Segmentation of Interstitial Lung Disease in Thoracic CTcited by 0
- 2026Prompt-Guided Interactive Segmentation of Interstitial Lung Disease in Thoracic CT28 Aug 2026
- 2026Jolia: Concept-Level Vision-Language Alignment for 3D CT Contrastive Learning23 Jun 2026
- 2025RadImageNet-VQA: A Large-Scale CT and MRI Dataset for Radiologic Visual Question Answering19 Dec 2025
- 2025Curia: A Multi-Modal Foundation Model for Radiology8 Sep 2025
- 2025RAPS-3D: Efficient interactive segmentation for 3D radiological imaging10 Jul 2025
- 2025CT-Agent: A Multimodal-LLM Agent for 3D CT Radiology Question Answering22 May 2025