CTI-Unet: Cascaded Threshold Integration for Improved U-Net Segmentation of Pathology Images

Chronic kidney disease (CKD) is a growing global health concern, necessitating precise and efficient image analysis to aid diagnosis and treatment planning. Automated segmentation of kidney pathology images plays a central role in facilitating clinical workflows, yet conventional segmentation models often require delicate threshold tuning. This paper proposes a novel textitCascaded Threshold-Integrated U-Net (CTI-Unet) to overcome the limitations of single-threshold segmentation. By sequentially integrating multiple thresholded outputs, our approach can reconcile noise suppression with the preservation of finer structural details. Experiments on the challenging KPIs2024 dataset demonstrate that CTI-Unet outperforms state-of-the-art architectures such as nnU-Net, Swin-Unet, and CE-Net, offering a robust and flexible framework for kidney pathology image segmentation.