RiskAgent: Synergizing Language Models with Validated Tools for Evidence-Based Risk Prediction

Large Language Models (LLMs) achieve competitive results compared to human experts in medical examinations. However, it remains a challenge to apply LLMs to complex clinical decision-making, which requires a deep understanding of medical knowledge and differs from the standardized, exam-style scenarios commonly used in current efforts. A common approach is to fine-tune LLMs for target tasks, which, however, not only requires substantial data and computational resources but also remains prone to generating `hallucinations'. In this work, we present RiskAgent, which synergizes language models with hundreds of validated clinical decision tools supported by evidence-based medicine, to provide generalizable and faithful recommendations. Our experiments show that RiskAgent not only achieves superior performance on a broad range of clinical risk predictions across diverse scenarios and diseases, but also demonstrates robust generalization in tool learning on the external MedCalc-Bench dataset, as well as in medical reasoning and question answering on three representative benchmarks, MedQA, MedMCQA, and MMLU.