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Can ChatGPT Diagnose Alzheimer's Disease?

arXiv 2502.06907 ↗First posted 10 Feb 2025cs.LG cs.AIcited by 0

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Abstract (arXiv)

Can ChatGPT diagnose Alzheimer's Disease (AD)? AD is a devastating neurodegenerative condition that affects approximately 1 in 9 individuals aged 65 and older, profoundly impairing memory and cognitive function. This paper utilises 9300 electronic health records (EHRs) with data from Magnetic Resonance Imaging (MRI) and cognitive tests to address an intriguing question: As a general-purpose task solver, can ChatGPT accurately detect AD using EHRs? We present an in-depth evaluation of ChatGPT using a black-box approach with zero-shot and multi-shot methods. This study unlocks ChatGPT's capability to analyse MRI and cognitive test results, as well as its potential as a diagnostic tool for AD. By automating aspects of the diagnostic process, this research opens a transformative approach for the healthcare system, particularly in addressing disparities in resource-limited regions where AD specialists are scarce. Hence, it offers a foundation for a promising method for early detection, supporting individuals with timely interventions, which is paramount for Quality of Life (QoL).

Key facts. No citing papers in the map yet (data through 14 Oct 2026). Builds on 19 of its 60 references that are in the map. First posted on arXiv 10 Feb 2025.

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19 of 60 references.

References · 19

  1. 2020Language Models are Few-Shot Learnerscited by 32,419
  2. 2023GPT-4 Technical Reportcited by 18,396
  3. 2023Toolformer: Language Models Can Teach Themselves to Use Toolscited by 4,182
  4. 2023Generative Agents: Interactive Simulacra of Human Behaviorcited by 3,568
  5. 2023Sparks of Artificial General Intelligence: Early experiments with GPT-4cited by 2,592
  6. 2022Survey of Hallucination in Natural Language Generationcited by 2,075
  7. 2022Language Models (Mostly) Know What They Knowcited by 1,856
  8. 2023Inference-Time Intervention: Eliciting Truthful Answers from a Language Modelcited by 1,302
  9. 2023A Multitask, Multilingual, Multimodal Evaluation of ChatGPT on Reasoning, Hallucination, and Interactivitycited by 894
  10. 2022Teaching Models to Express Their Uncertainty in Wordscited by 751
  11. 2023Is ChatGPT a General-Purpose Natural Language Processing Task Solver?cited by 488
  12. 2019Measuring Calibration in Deep Learningcited by 446
7 more
  1. 2023Is ChatGPT A Good Translator? Yes With GPT-4 As The Enginecited by 176
  2. 2023Is ChatGPT Fair for Recommendation? Evaluating Fairness in Large Language Model Recommendationcited by 114
  3. 2024Health-LLM: Large Language Models for Health Prediction via Wearable Sensor Datacited by 66
  4. 2023Multi-Prompts Learning with Cross-Modal Alignment for Attribute-based Person Re-Identificationcited by 20
  5. 2024Few-Shot Fairness: Unveiling LLM's Potential for Fairness-Aware Classificationcited by 18
  6. 2023Zero-shot information extraction from radiological reports using ChatGPTcited by 15
  7. 2024EEG-SSM: Leveraging State-Space Model for Dementia Detectioncited by 11

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