MCP-MedSAM: A Powerful Lightweight Medical Segment Anything Model Trained with a Single GPU in Just One Day
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Abstract (arXiv)
Medical image segmentation involves partitioning medical images into meaningful regions, with a focus on identifying anatomical structures and lesions. It has broad applications in healthcare, and deep learning methods have enabled significant advancements in automating this process. Recently, the introduction of the Segmentation Anything Model (SAM), the first foundation model for segmentation task, has prompted researchers to adapt it for the medical domain to improve performance across various tasks. However, SAM's large model size and high GPU requirements hinder its scalability and development in the medical domain. In this work, we propose MCP-MedSAM, a powerful and lightweight medical SAM model designed to be trainable on a single A100 GPU with 40GB of memory within one day while delivering superior segmentation performance. Recognizing the significant internal differences between modalities and the need for direct segmentation target information within bounding boxes, we introduce two kinds of prompts: the modality prompt and the content prompt. After passing through the prompt encoder, their embedding representations can further improve the segmentation performance by incorporating more relevant information without adding significant training overhead. Additionally, we adopt an effective modality-based data sampling strategy to address data imbalance between modalities, ensuring more balanced performance across all modalities. Our method was trained and evaluated using a large-scale challenge dataset, compared to top-ranking methods on the challenge leaderboard, MCP-MedSAM achieved superior performance while requiring only one day of training on a single GPU. The code is publicly available at textcolorbluehttps://github.com/dong845/MCP-MedSAM.
Key facts. Cited by 4 papers in the map (data through 14 Oct 2026). Builds on 35 of its 56 references that are in the map. First posted on arXiv 8 Dec 2024.
Builds on
35 of 56 references.
References · 35
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23 more
- 2022Swin UNETR: Swin Transformers for Semantic Segmentation of Brain Tumors in MRI Imagescited by 830
- 2022TotalSegmentator: robust segmentation of 104 anatomical structures in CT imagescited by 613
- 2023Segment Everything Everywhere All at Oncecited by 548
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- 2023Segment Anything in High Qualitycited by 376
- 2023Faster Segment Anything: Towards Lightweight SAM for Mobile Applicationscited by 352
- 2024VM-UNet: Vision Mamba UNet for Medical Image Segmentationcited by 287
- 2024Medical SAM 2: Segment medical images as video via Segment Anything Model 2cited by 154
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- 2023RepViT: Revisiting Mobile CNN From ViT Perspectivecited by 123
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- 2021Does CLIP Benefit Visual Question Answering in the Medical Domain as Much as it Does in the General Domain?cited by 85
- 2023SAM on Medical Images: A Comprehensive Study on Three Prompt Modescited by 82
- 2024TotalSegmentator MRI: Robust Sequence-independent Segmentation of Multiple Anatomic Structures in MRIcited by 59
- 2024LightM-UNet: Mamba Assists in Lightweight UNet for Medical Image Segmentationcited by 54
- 2023ScribblePrompt: Fast and Flexible Interactive Segmentation for Any Biomedical Imagecited by 48
- 2023UniSeg: A Prompt-driven Universal Segmentation Model as well as A Strong Representation Learnercited by 47
- 2023Training Like a Medical Resident: Context-Prior Learning Toward Universal Medical Image Segmentationcited by 33
- 2023DeSAM: Decoupled Segment Anything Model for Generalizable Medical Image Segmentationcited by 26
- 2023RepViT-SAM: Towards Real-Time Segmenting Anythingcited by 17
- 2023MedPrompt: Cross-Modal Prompting for Multi-Task Medical Image Translationcited by 13
- 2020MA-Unet: An improved version of Unet based on multi-scale and attention mechanism for medical image segmentationcited by 12
- 2024Swin-LiteMedSAM: A Lightweight Box-Based Segment Anything Model for Large-Scale Medical Image Datasetscited by 6
Built on by
Citing papers per year: 2025: 3; 2026: 1.
4 papers.
- 2025Vision Foundation Models in Medical Image Analysis: Advances and Challengescited by 9
- 2025SAMRI: Segment Any MRIcited by 2
- 2025Boundary-Aware Test-Time Adaptation for Zero-Shot Medical Image Segmentationcited by 0
- 2026ReG-SAM: Reference Graph-Driven SAM for 2D Foundational Vessel Segmentationcited by 0
- 2026ReG-SAM: Reference Graph-Driven SAM for 2D Foundational Vessel Segmentation25 Sep 2026
- 2025Boundary-Aware Test-Time Adaptation for Zero-Shot Medical Image Segmentation4 Dec 2025
- 2025SAMRI: Segment Any MRI30 Oct 2025
- 2025Vision Foundation Models in Medical Image Analysis: Advances and Challenges20 Feb 2025