MCICSAM: Monte Carlo-guided Interpolation Consistency Segment Anything Model for Semi-Supervised Prostate Zone Segmentation

Accurate segmentation of various regions within the prostate is pivotal for diagnosing and treating prostate-related diseases. However, the scarcity of labeled data, particularly in specialized medical fields like prostate imaging, poses a significant challenge. Segment Anything Model (SAM) is a new large model for natural image segmentation, but there are some challenges in medical imaging. In order to better utilize the powerful feature extraction capability of SAM as well as to address the problem of low data volume for medical image annotation, we use Low-Rank Adaptation (LoRA) and semi-supervised learning methods of Monte Carlo guided interpolation consistency (MCIC) to enhance the fine-tuned SAM. We propose Monte Carlo-guided Interpolation Consistency Segment Anything Model (MCICSAM) for application to semi-supervised learning based prostate region segmentation. In the unlabeled data section, MCIC performs two different interpolation transformations on the input data and incorporates Monte Carlo uncertainty analysis in the output, forcing the model to be consistent in its predictions. The consistency constraints imposed on these interpolated samples allow the model to fit the distribution of unlabeled data better, ultimately improving its performance in semi-supervised scenarios. We use Dice and Hausdorff Distance at 95th percentile (HD95) to validate model performance. MCICSAM yieldes Dice with 79.38% and 89.95%, along with improves HD95 values of 3.12 and 2.27 for transition zone and transition zone. At the same time MCICSAM demonstrates strong generalizability. This method is expected to bring new possibilities in the field of prostate image segmentation.