SegFormer3D: an Efficient Transformer for 3D Medical Image Segmentation
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Abstract (arXiv)
The adoption of Vision Transformers (ViTs) based architectures represents a significant advancement in 3D Medical Image (MI) segmentation, surpassing traditional Convolutional Neural Network (CNN) models by enhancing global contextual understanding. While this paradigm shift has significantly enhanced 3D segmentation performance, state-of-the-art architectures require extremely large and complex architectures with large scale computing resources for training and deployment. Furthermore, in the context of limited datasets, often encountered in medical imaging, larger models can present hurdles in both model generalization and convergence. In response to these challenges and to demonstrate that lightweight models are a valuable area of research in 3D medical imaging, we present SegFormer3D, a hierarchical Transformer that calculates attention across multiscale volumetric features. Additionally, SegFormer3D avoids complex decoders and uses an all-MLP decoder to aggregate local and global attention features to produce highly accurate segmentation masks. The proposed memory efficient Transformer preserves the performance characteristics of a significantly larger model in a compact design. SegFormer3D democratizes deep learning for 3D medical image segmentation by offering a model with 33x less parameters and a 13x reduction in GFLOPS compared to the current state-of-the-art (SOTA). We benchmark SegFormer3D against the current SOTA models on three widely used datasets Synapse, BRaTs, and ACDC, achieving competitive results. Code: https://github.com/OSUPCVLab/SegFormer3D.git
Key facts. Cited by 31 papers in the map (data through 7 Oct 2026). Builds on 25 of its 35 references that are in the map. First posted on arXiv 15 Apr 2024.
Builds on
25 of 35 references.
References · 25
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- 2015U-Net: Convolutional Networks for Biomedical Image Segmentationcited by 19,604
- 2014Fully Convolutional Networks for Semantic Segmentationcited by 4,845
- 2021SegFormer: Simple and Efficient Design for Semantic Segmentation with Transformerscited by 2,923
- 2016V-Net: Fully Convolutional Neural Networks for Volumetric Medical Image Segmentationcited by 2,284
- 2021Pyramid Vision Transformer: A Versatile Backbone for Dense Prediction without Convolutionscited by 1,960
- 2021TransUNet: Transformers Make Strong Encoders for Medical Image Segmentationcited by 1,552
- 20163D U-Net: Learning Dense Volumetric Segmentation from Sparse Annotationcited by 1,471
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- 2021Swin-Unet: Unet-like Pure Transformer for Medical Image Segmentationcited by 1,218
- 2021UNETR: Transformers for 3D Medical Image Segmentationcited by 954
- 2022Swin UNETR: Swin Transformers for Semantic Segmentation of Brain Tumors in MRI Imagescited by 823
13 more
- 2018nnU-Net: Self-adapting Framework for U-Net-Based Medical Image Segmentationcited by 291
- 2021TransBTS: Multimodal Brain Tumor Segmentation Using Transformercited by 265
- 2021TransFuse: Fusing Transformers and CNNs for Medical Image Segmentationcited by 258
- 2021CoTr: Efficiently Bridging CNN and Transformer for 3D Medical Image Segmentationcited by 227
- 2023EfficientViT: Memory Efficient Vision Transformer with Cascaded Group Attentioncited by 172
- 2020How Much Position Information Do Convolutional Neural Networks Encode?cited by 171
- 2021LeViT-UNet: Make Faster Encoders with Transformer for Medical Image Segmentationcited by 85
- 20163D Deeply Supervised Network for Automatic Liver Segmentation from CT Volumescited by 43
- 2021TransClaw U-Net: Claw U-Net with Transformers for Medical Image Segmentationcited by 41
- 2017Deeply-Supervised CNN for Prostate Segmentationcited by 30
- 2017Hierarchical 3D fully convolutional networks for multi-organ segmentationcited by 19
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Citing papers per year: 2024: 6; 2025: 18; 2026: 7.
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- 2026RefineFormer3D: Efficient 3D Medical Image Segmentation via Adaptive Multi-Scale Transformer with Cross Attention Fusion18 Feb 2026
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- 2025OmniMamba4D: Spatio-temporal Mamba for longitudinal CT lesion segmentation13 Apr 2025
- 2025A Comprehensive Analysis of Mamba for 3D Volumetric Medical Image Segmentation25 Mar 2025
- 2025Federated nnU-Net for Privacy-Preserving Medical Image Segmentation4 Mar 2025
- 2025No More Sliding Window: Efficient 3D Medical Image Segmentation with Differentiable Top-k Patch Sampling18 Jan 2025
- 2025Interpretable Auto Window Setting for Deep-Learning-Based CT Analysis7 Jan 2025
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- 2024Frequency-Guided Masking for Enhanced Vision Self-Supervised Learning16 Sep 2024
- 2024DetailCLIP: Detail-Oriented CLIP for Fine-Grained Tasks10 Sep 2024
- 2024MobileUNETR: A Lightweight End-To-End Hybrid Vision Transformer For Efficient Medical Image Segmentation4 Sep 2024
- 2024DocParseNet: Advanced Semantic Segmentation and OCR Embeddings for Efficient Scanned Document Annotation25 Jun 2024
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- 2025DM-SegNet: Dual-Mamba Architecture for 3D Medical Image Segmentation with Global Context Modelingcited by 0
- 2025ASM-UNet: Adaptive Scan Mamba Integrating Group Commonalities and Individual Variations for Fine-Grained Segmentationcited by 0
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- 2025ASM-UNet: Adaptive Scan Mamba Integrating Group Commonalities and Individual Variations for Fine-Grained Segmentation10 Aug 2025
- 2025DM-SegNet: Dual-Mamba Architecture for 3D Medical Image Segmentation with Global Context Modeling5 Jun 2025
- 2025OmniMamba4D: Spatio-temporal Mamba for longitudinal CT lesion segmentation13 Apr 2025
- 2025A Comprehensive Analysis of Mamba for 3D Volumetric Medical Image Segmentation25 Mar 2025
- 2024DetailCLIP: Detail-Oriented CLIP for Fine-Grained Taskscited by 15
- 2024DetailCLIP: Detail-Oriented CLIP for Fine-Grained Tasks10 Sep 2024
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- 2024MobileUNETR: A Lightweight End-To-End Hybrid Vision Transformer For Efficient Medical Image Segmentationcited by 6
- 2025No More Sliding Window: Efficient 3D Medical Image Segmentation with Differentiable Top-k Patch Samplingcited by 5
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- 2025Federated nnU-Net for Privacy-Preserving Medical Image Segmentationcited by 3
- 2025FuseUNet: A Multi-Scale Feature Fusion Method for U-like Networkscited by 3
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- 2025Spatial-Aware Self-Supervision for Medical 3D Imaging with Multi-Granularity Observable Taskscited by 1
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12 most cited of 23 All 23 (JSON)
- 2026TRACE-Seg3D: Counterfactual Context Auditing For Robust 3D Glioma Segmentation Under Institutional Shift8 Jul 2026
- 2026SEMIR: Semantic Minor-Induced Representation Learning on Graphs for Visual Segmentation12 May 2026
- 2026GPAFormer: Graph-guided Patch Aggregation Transformer for Efficient 3D Medical Image Segmentation8 Apr 2026
- 2026ILV: Iterative Latent Volumes for Fast and Accurate Sparse-View CT Reconstruction16 Mar 2026
- 2026RefineFormer3D: Efficient 3D Medical Image Segmentation via Adaptive Multi-Scale Transformer with Cross Attention Fusion18 Feb 2026
- 2025Breast Cancer Neoadjuvant Chemotherapy Treatment Response Prediction Using Aligned Longitudinal MRI and Clinical Data19 Dec 2025
- 2025PF-DAformer: Proximal Femur Segmentation via Domain Adaptive Transformer for Dual-Center QCT30 Oct 2025
- 2025Johnson-Lindenstrauss Lemma Guided Network for Efficient 3D Medical Segmentation26 Sep 2025
- 2025Citrus-V: Advancing Medical Foundation Models with Unified Medical Image Grounding for Clinical Reasoning23 Sep 2025
- 2025Frequency-Aware Ensemble Learning for BraTS 2025 Pediatric Brain Tumor Segmentation18 Sep 2025
- 2025Spatial-Aware Self-Supervision for Medical 3D Imaging with Multi-Granularity Observable Tasks7 Sep 2025
- 2025SegFormer Fine-Tuning with Dropout: Advancing Hair Artifact Removal in Skin Lesion Analysis2 Sep 2025
12 newest of 23 All 23 (JSON)