RAmBLA: A Framework for Evaluating the Reliability of LLMs as Assistants in the Biomedical Domain
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Abstract (arXiv)
Large Language Models (LLMs) increasingly support applications in a wide range of domains, some with potential high societal impact such as biomedicine, yet their reliability in realistic use cases is under-researched. In this work we introduce the Reliability AssesMent for Biomedical LLM Assistants (RAmBLA) framework and evaluate whether four state-of-the-art foundation LLMs can serve as reliable assistants in the biomedical domain. We identify prompt robustness, high recall, and a lack of hallucinations as necessary criteria for this use case. We design shortform tasks and tasks requiring LLM freeform responses mimicking real-world user interactions. We evaluate LLM performance using semantic similarity with a ground truth response, through an evaluator LLM.
Key facts. Cited by 4 papers in the map (data through 14 Oct 2026). Builds on 29 of its 39 references that are in the map. First posted on arXiv 21 Mar 2024.
Builds on
29 of 39 references.
References · 29
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17 more
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Citing papers per year: 2024: 1; 2025: 2; 2026: 1.
4 papers.
- 2024The Need for Guardrails with Large Language Models in Medical Safety-Critical Settings: An Artificial Intelligence Application in the Pharmacovigilance Ecosystemcited by 11
- 2025Towards Agents That Know When They Don't Know: Uncertainty as a Control Signal for Structured Reasoningcited by 10
- 2025Trusting CHATGPT: how minor tweaks in the prompts lead to major differences in sentiment classificationcited by 0
- 2026When Large Language Models Fail in Healthcare: Evaluating Sensitivity to Prompt Variationscited by 0
- 2026When Large Language Models Fail in Healthcare: Evaluating Sensitivity to Prompt Variations5 Jun 2026
- 2025Towards Agents That Know When They Don't Know: Uncertainty as a Control Signal for Structured Reasoning2 Sep 2025
- 2025Trusting CHATGPT: how minor tweaks in the prompts lead to major differences in sentiment classification16 Apr 2025
- 2024The Need for Guardrails with Large Language Models in Medical Safety-Critical Settings: An Artificial Intelligence Application in the Pharmacovigilance Ecosystem1 Jul 2024