The Brain Tumor Segmentation (BraTS) Challenge 2023: Brain MR Image Synthesis for Tumor Segmentation (BraSyn)
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Abstract (arXiv)
Automated brain tumor segmentation methods have become well-established and reached performance levels offering clear clinical utility. These methods typically rely on four input magnetic resonance imaging (MRI) modalities: T1-weighted images with and without contrast enhancement, T2-weighted images, and FLAIR images. However, some sequences are often missing in clinical practice due to time constraints or image artifacts, such as patient motion. Consequently, the ability to substitute missing modalities and gain segmentation performance is highly desirable and necessary for the broader adoption of these algorithms in the clinical routine. In this work, we present the establishment of the Brain MR Image Synthesis Benchmark (BraSyn) in conjunction with the Medical Image Computing and Computer-Assisted Intervention (MICCAI) 2023. The primary objective of this challenge is to evaluate image synthesis methods that can realistically generate missing MRI modalities when multiple available images are provided. The ultimate aim is to facilitate automated brain tumor segmentation pipelines. The image dataset used in the benchmark is diverse and multi-modal, created through collaboration with various hospitals and research institutions.
Key facts. Cited by 24 papers in the map (data through 14 Oct 2026). Builds on 7 of its 27 references that are in the map. First posted on arXiv 15 May 2023.
Builds on
7 of 27 references.
References · 7
- 2021The RSNA-ASNR-MICCAI BraTS 2021 Benchmark on Brain Tumor Segmentation and Radiogenomic Classificationcited by 518
- 2018Identifying the Best Machine Learning Algorithms for Brain Tumor Segmentation, Progression Assessment, and Overall Survival Prediction in the BRATS Challengecited by 511
- 2016Efficient Multi-Scale 3D CNN with Fully Connected CRF for Accurate Brain Lesion Segmentationcited by 263
- 2017Medical Image Analysis using Convolutional Neural Networks: A Reviewcited by 99
- 2020Joint super-resolution and synthesis of 1 mm isotropic MP-RAGE volumes from clinical MRI exams with scans of different orientation, resolution and contrastcited by 45
- 2019DiamondGAN: Unified Multi-Modal Generative Adversarial Networks for MRI Sequences Synthesiscited by 36
- 2022Domain-Adaptive 3D Medical Image Synthesis: An Efficient Unsupervised Approachcited by 8
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Citing papers per year: 2023: 2; 2024: 12; 2025: 5; 2026: 5.
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- 2024Similarity and Quality Metrics for MR Image-To-Image Translationcited by 20
- 2024cWDM: Conditional Wavelet Diffusion Models for Cross-Modality 3D Medical Image Synthesiscited by 19
- 2024Medical Vision Generalist: Unifying Medical Imaging Tasks in Contextcited by 13
- 20242.5D Multi-view Averaging Diffusion Model for 3D Medical Image Translation: Application to Low-count PET Reconstruction with CT-less Attenuation Correctioncited by 13
- 2024BraTS-PEDs: Results of the Multi-Consortium International Pediatric Brain Tumor Segmentation Challenge 2023cited by 11
- 2024BraSyn 2023 challenge: Missing MRI synthesis and the effect of different learning objectivescited by 7
- 2024Model Ensemble for Brain Tumor Segmentation in Magnetic Resonance Imagingcited by 7
- 2023MRI Scan Synthesis Methods based on Clustering and Pix2Pixcited by 6
- 2024Five Pitfalls When Assessing Synthetic Medical Images with Reference Metricscited by 4
- 2024Brain Tumour Removing and Missing Modality Generation using 3D WDMcited by 4
- 2024Learning Modality-Aware Representations: Adaptive Group-wise Interaction Network for Multimodal MRI Synthesiscited by 4
- 2023CoNeS: Conditional neural fields with shift modulation for multi-sequence MRI translationcited by 3
12 more
- 2024CAVM: Conditional Autoregressive Vision Model for Contrast-Enhanced Brain Tumor MRI Synthesiscited by 3
- 2025The MICCAI Federated Tumor Segmentation (FeTS) Challenge 2024: Efficient and Robust Aggregation Methods for Federated Learningcited by 3
- 2026Contrast-X: A Multi-Modal Contrast Image Synthesis Benchmark and Universal Modality Flow Matchingcited by 2
- 2024Implantable Adaptive Cells: A Novel Enhancement for Pre-Trained U-Nets in Medical Image Segmentationcited by 1
- 2025Attention Xception UNet (AXUNet): A Novel Combination of CNN and Self-Attention for Brain Tumor Segmentationcited by 1
- 2025Multi-modal Contrastive Learning for Tumor-specific Missing Modality Synthesiscited by 0
- 2025DEMIST: Decoupled Multi-stream latent diffusion for Quantitative Myelin Map Synthesiscited by 0
- 2025Not Quite Anything: Overcoming SAMs Limitations for 3D Medical Imagingcited by 0
- 2026Reliable Brain Tumor Segmentation Based on Spiking Neural Networks with Efficient Trainingcited by 0
- 2026MHMamba: Multi-Head Mamba for 3D Brain Tumor Segmentationcited by 0
- 2026Seeing What Is Actually There: PriVE-Bench and PriVE-Tools for Counterfactual Evaluation of Agentic Visual Evidence in VLMscited by 0
- 2026MRIComp4Flow: Compression of 3D Brain MRI for Training Multi-Modal Generative Modelscited by 0
- 2026MRIComp4Flow: Compression of 3D Brain MRI for Training Multi-Modal Generative Models10 Aug 2026
- 2026Seeing What Is Actually There: PriVE-Bench and PriVE-Tools for Counterfactual Evaluation of Agentic Visual Evidence in VLMs14 Jul 2026
- 2026MHMamba: Multi-Head Mamba for 3D Brain Tumor Segmentation15 May 2026
- 2026Reliable Brain Tumor Segmentation Based on Spiking Neural Networks with Efficient Training23 Jan 2026
- 2026Contrast-X: A Multi-Modal Contrast Image Synthesis Benchmark and Universal Modality Flow Matching22 Jan 2026
- 2025The MICCAI Federated Tumor Segmentation (FeTS) Challenge 2024: Efficient and Robust Aggregation Methods for Federated Learning5 Dec 2025
- 2025Not Quite Anything: Overcoming SAMs Limitations for 3D Medical Imaging22 Nov 2025
- 2025DEMIST: Decoupled Multi-stream latent diffusion for Quantitative Myelin Map Synthesis16 Nov 2025
- 2025Attention Xception UNet (AXUNet): A Novel Combination of CNN and Self-Attention for Brain Tumor Segmentation26 Mar 2025
- 2025Multi-modal Contrastive Learning for Tumor-specific Missing Modality Synthesis26 Feb 2025
- 2024cWDM: Conditional Wavelet Diffusion Models for Cross-Modality 3D Medical Image Synthesis26 Nov 2024
- 2024Learning Modality-Aware Representations: Adaptive Group-wise Interaction Network for Multimodal MRI Synthesis22 Nov 2024
12 more
- 2024Brain Tumour Removing and Missing Modality Generation using 3D WDM7 Nov 2024
- 2024Model Ensemble for Brain Tumor Segmentation in Magnetic Resonance Imaging12 Sep 2024
- 2024Five Pitfalls When Assessing Synthetic Medical Images with Reference Metrics12 Aug 2024
- 2024BraTS-PEDs: Results of the Multi-Consortium International Pediatric Brain Tumor Segmentation Challenge 202311 Jul 2024
- 2024CAVM: Conditional Autoregressive Vision Model for Contrast-Enhanced Brain Tumor MRI Synthesis23 Jun 2024
- 20242.5D Multi-view Averaging Diffusion Model for 3D Medical Image Translation: Application to Low-count PET Reconstruction with CT-less Attenuation Correction12 Jun 2024
- 2024Medical Vision Generalist: Unifying Medical Imaging Tasks in Context8 Jun 2024
- 2024Similarity and Quality Metrics for MR Image-To-Image Translation14 May 2024
- 2024Implantable Adaptive Cells: A Novel Enhancement for Pre-Trained U-Nets in Medical Image Segmentation6 May 2024
- 2024BraSyn 2023 challenge: Missing MRI synthesis and the effect of different learning objectives12 Mar 2024
- 2023MRI Scan Synthesis Methods based on Clustering and Pix2Pix8 Dec 2023
- 2023CoNeS: Conditional neural fields with shift modulation for multi-sequence MRI translation6 Sep 2023
- 2024cWDM: Conditional Wavelet Diffusion Models for Cross-Modality 3D Medical Image Synthesiscited by 19
- 20242.5D Multi-view Averaging Diffusion Model for 3D Medical Image Translation: Application to Low-count PET Reconstruction with CT-less Attenuation Correctioncited by 13
- 2026Contrast-X: A Multi-Modal Contrast Image Synthesis Benchmark and Universal Modality Flow Matchingcited by 2
- 2025DEMIST: Decoupled Multi-stream latent diffusion for Quantitative Myelin Map Synthesiscited by 0
- 2026Contrast-X: A Multi-Modal Contrast Image Synthesis Benchmark and Universal Modality Flow Matching22 Jan 2026
- 2025DEMIST: Decoupled Multi-stream latent diffusion for Quantitative Myelin Map Synthesis16 Nov 2025
- 2024cWDM: Conditional Wavelet Diffusion Models for Cross-Modality 3D Medical Image Synthesis26 Nov 2024
- 20242.5D Multi-view Averaging Diffusion Model for 3D Medical Image Translation: Application to Low-count PET Reconstruction with CT-less Attenuation Correction12 Jun 2024
- 2026MHMamba: Multi-Head Mamba for 3D Brain Tumor Segmentation15 May 2026
- 2024Similarity and Quality Metrics for MR Image-To-Image Translationcited by 20
- 2024Medical Vision Generalist: Unifying Medical Imaging Tasks in Contextcited by 13
- 2024BraTS-PEDs: Results of the Multi-Consortium International Pediatric Brain Tumor Segmentation Challenge 2023cited by 11
- 2024BraSyn 2023 challenge: Missing MRI synthesis and the effect of different learning objectivescited by 7
- 2024Model Ensemble for Brain Tumor Segmentation in Magnetic Resonance Imagingcited by 7
- 2023MRI Scan Synthesis Methods based on Clustering and Pix2Pixcited by 6
- 2024Five Pitfalls When Assessing Synthetic Medical Images with Reference Metricscited by 4
- 2024Brain Tumour Removing and Missing Modality Generation using 3D WDMcited by 4
- 2024Learning Modality-Aware Representations: Adaptive Group-wise Interaction Network for Multimodal MRI Synthesiscited by 4
- 2023CoNeS: Conditional neural fields with shift modulation for multi-sequence MRI translationcited by 3
- 2024CAVM: Conditional Autoregressive Vision Model for Contrast-Enhanced Brain Tumor MRI Synthesiscited by 3
- 2025The MICCAI Federated Tumor Segmentation (FeTS) Challenge 2024: Efficient and Robust Aggregation Methods for Federated Learningcited by 3
12 most cited of 18 All 18 (JSON)
- 2026MRIComp4Flow: Compression of 3D Brain MRI for Training Multi-Modal Generative Models10 Aug 2026
- 2026Reliable Brain Tumor Segmentation Based on Spiking Neural Networks with Efficient Training23 Jan 2026
- 2025The MICCAI Federated Tumor Segmentation (FeTS) Challenge 2024: Efficient and Robust Aggregation Methods for Federated Learning5 Dec 2025
- 2025Not Quite Anything: Overcoming SAMs Limitations for 3D Medical Imaging22 Nov 2025
- 2025Attention Xception UNet (AXUNet): A Novel Combination of CNN and Self-Attention for Brain Tumor Segmentation26 Mar 2025
- 2025Multi-modal Contrastive Learning for Tumor-specific Missing Modality Synthesis26 Feb 2025
- 2024Learning Modality-Aware Representations: Adaptive Group-wise Interaction Network for Multimodal MRI Synthesis22 Nov 2024
- 2024Brain Tumour Removing and Missing Modality Generation using 3D WDM7 Nov 2024
- 2024Model Ensemble for Brain Tumor Segmentation in Magnetic Resonance Imaging12 Sep 2024
- 2024Five Pitfalls When Assessing Synthetic Medical Images with Reference Metrics12 Aug 2024
- 2024BraTS-PEDs: Results of the Multi-Consortium International Pediatric Brain Tumor Segmentation Challenge 202311 Jul 2024
- 2024CAVM: Conditional Autoregressive Vision Model for Contrast-Enhanced Brain Tumor MRI Synthesis23 Jun 2024
12 newest of 18 All 18 (JSON)