mlsanityData to 7 Oct 2026

Mixed Transformer U-Net For Medical Image Segmentation

arXiv 2111.04734 ↗First posted 8 Nov 2021eess.IV cs.AI cs.CVcited by 95

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Abstract (arXiv)

Though U-Net has achieved tremendous success in medical image segmentation tasks, it lacks the ability to explicitly model long-range dependencies. Therefore, Vision Transformers have emerged as alternative segmentation structures recently, for their innate ability of capturing long-range correlations through Self-Attention (SA). However, Transformers usually rely on large-scale pre-training and have high computational complexity. Furthermore, SA can only model self-affinities within a single sample, ignoring the potential correlations of the overall dataset. To address these problems, we propose a novel Transformer module named Mixed Transformer Module (MTM) for simultaneous inter- and intra- affinities learning. MTM first calculates self-affinities efficiently through our well-designed Local-Global Gaussian-Weighted Self-Attention (LGG-SA). Then, it mines inter-connections between data samples through External Attention (EA). By using MTM, we construct a U-shaped model named Mixed Transformer U-Net (MT-UNet) for accurate medical image segmentation. We test our method on two different public datasets, and the experimental results show that the proposed method achieves better performance over other state-of-the-art methods. The code is available at: https://github.com/Dootmaan/MT-UNet.

Key facts. Cited by 95 papers in the map (data through 7 Oct 2026). Builds on 19 of its 21 references that are in the map. First posted on arXiv 8 Nov 2021.

Builds on

19 of 21 references.

References · 19

  1. 2017Attention Is All You Needcited by 59,932
  2. 2014Adam: A Method for Stochastic Optimizationcited by 36,960
  3. 2020An Image is Worth 16x16 Words: Transformers for Image Recognition at Scalecited by 29,915
  4. 2015U-Net: Convolutional Networks for Biomedical Image Segmentationcited by 19,604
  5. 2020End-to-End Object Detection with Transformerscited by 7,384
  6. 2016V-Net: Fully Convolutional Neural Networks for Volumetric Medical Image Segmentationcited by 2,284
  7. 2021TransUNet: Transformers Make Strong Encoders for Medical Image Segmentationcited by 1,552
  8. 2018UNet++: A Nested U-Net Architecture for Medical Image Segmentationcited by 1,518
  9. 2021Swin-Unet: Unet-like Pure Transformer for Medical Image Segmentationcited by 1,218
  10. 2019Axial Attention in Multidimensional Transformerscited by 350
  11. 2020UNet 3+: A Full-Scale Connected UNet for Medical Image Segmentationcited by 331
  12. 2018Attention Gated Networks: Learning to Leverage Salient Regions in Medical Imagescited by 271
7 more
  1. 2021TransBTS: Multimodal Brain Tumor Segmentation Using Transformercited by 265
  2. 2021TransFuse: Fusing Transformers and CNNs for Medical Image Segmentationcited by 258
  3. 2019Pay Less Attention with Lightweight and Dynamic Convolutionscited by 211
  4. 2021Beyond Self-attention: External Attention using Two Linear Layers for Visual Taskscited by 109
  5. 2019TENER: Adapting Transformer Encoder for Named Entity Recognitioncited by 69
  6. 2020Domain Adaptive Relational Reasoning for 3D Multi-Organ Segmentationcited by 48
  7. 2021TransClaw U-Net: Claw U-Net with Transformers for Medical Image Segmentationcited by 41

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Cited by year (2026 to 7 Oct)

Citing papers per year: 2022: 18; 2023: 19; 2024: 28; 2025: 22; 2026: 8.

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  1. 2024VM-UNet: Vision Mamba UNet for Medical Image Segmentationcited by 286
  2. 2022Medical Image Segmentation Review: The success of U-Netcited by 190
  3. 2024EMCAD: Efficient Multi-scale Convolutional Attention Decoding for Medical Image Segmentationcited by 64
  4. 2022Transformers in Medical Image Analysis: A Reviewcited by 41
  5. 2023Multi-scale Hierarchical Vision Transformer with Cascaded Attention Decoding for Medical Image Segmentationcited by 34
  6. 2022Transforming medical imaging with Transformers? A comparative review of key properties, current progresses, and future perspectivescited by 32
  7. 2022The Fully Convolutional Transformer for Medical Image Segmentationcited by 31
  8. 2023Ladder Fine-tuning approach for SAM integrating complementary networkcited by 25
  9. 2022Transformer Meets Boundary Value Inverse Problemscited by 22
  10. 2023G-CASCADE: Efficient Cascaded Graph Convolutional Decoding for 2D Medical Image Segmentationcited by 21
  11. 2023DA-TransUNet: Integrating Spatial and Channel Dual Attention with Transformer U-Net for Medical Image Segmentationcited by 16
  12. 2022BATFormer: Towards Boundary-Aware Lightweight Transformer for Efficient Medical Image Segmentationcited by 14
38 more
  1. 2022Optimizing Vision Transformers for Medical Image Segmentationcited by 12
  2. 2023MIST: Medical Image Segmentation Transformer with Convolutional Attention Mixing (CAM) Decodercited by 12
  3. 2024CSWin-UNet: Transformer UNet with Cross-Shaped Windows for Medical Image Segmentationcited by 12
  4. 2024MetaSeg: MetaFormer-based Global Contexts-aware Network for Efficient Semantic Segmentationcited by 12
  5. 2024SliceMamba with Neural Architecture Search for Medical Image Segmentationcited by 11
  6. 2022The Lighter The Better: Rethinking Transformers in Medical Image Segmentation Through Adaptive Pruningcited by 9
  7. 2022Recent Progress in Transformer-based Medical Image Analysiscited by 9
  8. 2023Attention Mechanisms in Medical Image Segmentation: A Surveycited by 9
  9. 2024D-Net: Dynamic Large Kernel with Dynamic Feature Fusion for Volumetric Medical Image Segmentationcited by 9
  10. 2025Vision Foundation Models in Medical Image Analysis: Advances and Challengescited by 9
  11. 2022MEW-UNet: Multi-axis representation learning in frequency domain for medical image segmentationcited by 8
  12. 2024PSFHS Challenge Report: Pubic Symphysis and Fetal Head Segmentation from Intrapartum Ultrasound Imagescited by 8
  13. 2022BirdSoundsDenoising: Deep Visual Audio Denoising for Bird Soundscited by 7
  14. 2025RWKV-UNet: Improving UNet with Long-Range Cooperation for Effective Medical Image Segmentationcited by 7
  15. 2022UNet-2022: Exploring Dynamics in Non-isomorphic Architecturecited by 6
  16. 2024A Comparative Survey of Vision Transformers for Feature Extraction in Texture Analysiscited by 6
  17. 2024CNN-Transformer Rectified Collaborative Learning for Medical Image Segmentationcited by 6
  18. 2024LV-UNet: A Lightweight and Vanilla Model for Medical Image Segmentationcited by 6
  19. 2025SRMamba: Mamba for Super-Resolution of LiDAR Point Cloudscited by 5
  20. 2025CENet: Context Enhancement Network for Medical Image Segmentationcited by 5
  21. 2022Annotation by Clicks: A Point-Supervised Contrastive Variance Method for Medical Semantic Segmentationcited by 4
  22. 2022Valuing Vicinity: Memory attention framework for context-based semantic segmentation in histopathologycited by 3
  23. 2023Towards more precise automatic analysis: a comprehensive survey of deep learning-based multi-organ segmentationcited by 3
  24. 2023Multiscale Progressive Text Prompt Network for Medical Image Segmentationcited by 3
  25. 2023Medical Image Segmentation via Sparse Coding Decodercited by 3
  26. 2023Complex Image Generation SwinTransformer Network for Audio Denoisingcited by 3
  27. 2023Learning Multi-axis Representation in Frequency Domain for Medical Image Segmentationcited by 3
  28. 2024Deep models for stroke segmentation: do complex architectures always perform better?cited by 3
  29. 2024AgileFormer: Spatially Agile Transformer UNet for Medical Image Segmentationcited by 3
  30. 2024Rethinking Attention Gated with Hybrid Dual Pyramid Transformer-CNN for Generalized Segmentation in Medical Imagingcited by 3
  31. 2024Are Vision xLSTM Embedded UNet More Reliable in Medical 3D Image Segmentation?cited by 3
  32. 2025Merging Context Clustering with Visual State Space Models for Medical Image Segmentationcited by 3
  33. 2025OSDMamba: Enhancing Oil Spill Detection from Remote Sensing Images Using Selective State Space Modelcited by 3
  34. 2025UltraLBM-UNet: Ultralight Bidirectional Mamba-based Model for Skin Lesion Segmentationcited by 3
  35. 2022Exemplar Learning for Medical Image Segmentationcited by 2
  36. 2023Self-pruning Graph Neural Network for Predicting Inflammatory Disease Activity in Multiple Sclerosis from Brain MR Imagescited by 2
  37. 2023DPATD: Dual-Phase Audio Transformer for Denoisingcited by 2
  38. 2023AI-SAM: Automatic and Interactive Segment Anything Modelcited by 2

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