Semiparametric proximal causal inference
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Abstract (arXiv)
Skepticism about the assumption of no unmeasured confounding, also known as exchangeability, is often warranted in making causal inferences from observational data; because exchangeability hinges on an investigator's ability to accurately measure covariates that capture all potential sources of confounding. In practice, the most one can hope for is that covariate measurements are at best proxies of the true underlying confounding mechanism operating in a given observational study. In this paper, we consider the framework of proximal causal inference introduced by Miao et al. (2018); Tchetgen Tchetgen et al. (2020), which while explicitly acknowledging covariate measurements as imperfect proxies of confounding mechanisms, offers an opportunity to learn about causal effects in settings where exchangeability on the basis of measured covariates fails. We make a number of contributions to proximal inference including (i) an alternative set of conditions for nonparametric proximal identification of the average treatment effect; (ii) general semiparametric theory for proximal estimation of the average treatment effect including efficiency bounds for key semiparametric models of interest; (iii) a characterization of proximal doubly robust and locally efficient estimators of the average treatment effect. Moreover, we provide analogous identification and efficiency results for the average treatment effect on the treated. Our approach is illustrated via simulation studies and a data application on evaluating the effectiveness of right heart catheterization in the intensive care unit of critically ill patients.
Key facts. Cited by 58 papers in the map (data through 7 Oct 2026). First posted on arXiv 17 Nov 2020.
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Citing papers per year: 2021: 8; 2022: 10; 2023: 11; 2024: 10; 2025: 11; 2026: 8.
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50 most cited of 58 All 58 (JSON)
- 2026Proximal Balancing for Causal Effect Estimation under Unmeasured Confounding30 Sep 2026
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- 2026Nonparametric Instrumental Variable Analysis Without Structural Equations: Debiased Inference on Functionals of Inverse Problems with No Solutions27 Apr 2026
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- 2025Density Ratio-Free Doubly Robust Proxy Causal Learning26 May 2025
- 2025Reinforcement Learning with Continuous Actions Under Unmeasured Confounding1 May 2025
- 2025DeCaFlow: A deconfounding causal generative model19 Mar 2025
- 2025Detecting clinician implicit biases in diagnoses using proximal causal inference27 Jan 2025
- 2024Controlling for Unobserved Confounding with Large Language Model Classification of Patient Smoking Status5 Nov 2024
- 2024DNA-SE: Towards Deep Neural-Nets Assisted Semiparametric Estimation4 Aug 2024
- 2024Identifiable Latent Bandits: Leveraging observational data for personalized decision-making23 Jul 2024
- 2024REVEAL-IT: REinforcement learning with Visibility of Evolving Agent poLicy for InTerpretability20 Jun 2024
- 2024Stochastic Optimization Algorithms for Instrumental Variable Regression with Streaming Data29 May 2024
- 2024Simplifying debiased inference via automatic differentiation and probabilistic programming14 May 2024
- 2024Recovering Latent Confounders from High-dimensional Proxy Variables21 Mar 2024
- 2024Proxy Methods for Domain Adaptation12 Mar 2024
- 2024Regularized DeepIV with Model Selection7 Mar 2024
- 2024Applied Causal Inference Powered by ML and AI4 Mar 2024
- 2023AI in Pharma for Personalized Sequential Decision-Making: Methods, Applications and Opportunities30 Nov 2023
- 2023A Semiparametric Instrumented Difference-in-Differences Approach to Policy Learning14 Oct 2023
- 2023The Blessings of Multiple Treatments and Outcomes in Treatment Effect Estimation29 Sep 2023
- 2023Doubly Robust Proximal Causal Learning for Continuous Treatments22 Sep 2023
- 2023Source Condition Double Robust Inference on Functionals of Inverse Problems25 Jul 2023
- 2023Balanced Filtering via Disclosure-Controlled Proxies26 Jun 2023
- 2023Assumption-lean falsification tests of rate double-robustness of double-machine-learning estimators18 Jun 2023
- 2023Partial Identification of Causal Effects Using Proxy Variables10 Apr 2023
- 2023A Unified Framework of Policy Learning for Contextual Bandit with Confounding Bias and Missing Observations20 Mar 2023
- 2023Minimax Instrumental Variable Regression and L2 Convergence Guarantees without Identification or Closedness10 Feb 2023
- 2023Proximal Causal Learning of Conditional Average Treatment Effects26 Jan 2023
- 2022An Instrumental Variable Approach to Confounded Off-Policy Evaluation29 Dec 2022
- 2022Optimal Treatment Regimes for Proximal Causal Learning19 Dec 2022
- 2022Estimating individual treatment effects under unobserved confounding using binary instruments17 Aug 2022
- 2022Inference on Strongly Identified Functionals of Weakly Identified Functions17 Aug 2022
- 2022Future-Dependent Value-Based Off-Policy Evaluation in POMDPs26 Jul 2022
- 2022Provably Efficient Reinforcement Learning in Partially Observable Dynamical Systems24 Jun 2022
- 2022Pessimism in the Face of Confounders: Provably Efficient Offline Reinforcement Learning in Partially Observable Markov Decision Processes26 May 2022
- 2022Deep Learning Methods for Proximal Inference via Maximum Moment Restriction19 May 2022
- 2022Partial Identification with Noisy Covariates: A Robust Optimization Approach22 Feb 2022
- 2022Long-term Causal Inference Under Persistent Confounding via Data Combination15 Feb 2022
50 newest of 58 All 58 (JSON)
- 2021Proximal Reinforcement Learning: Efficient Off-Policy Evaluation in Partially Observed Markov Decision Processescited by 40
- 2022Pessimism in the Face of Confounders: Provably Efficient Offline Reinforcement Learning in Partially Observable Markov Decision Processescited by 26
- 2026Off-Policy Evaluation for Missingness-Aware Policies in MDPs with Rewards Missing Not at Randomcited by 0
- 2026Off-Policy Evaluation for Missingness-Aware Policies in MDPs with Rewards Missing Not at Random18 Jun 2026
- 2022Pessimism in the Face of Confounders: Provably Efficient Offline Reinforcement Learning in Partially Observable Markov Decision Processes26 May 2022
- 2021Proximal Reinforcement Learning: Efficient Off-Policy Evaluation in Partially Observed Markov Decision Processes28 Oct 2021
- 2025Doubly Robust Alignment for Large Language Modelscited by 11
- 2025Doubly Robust Alignment for Large Language Models1 Jun 2025
- 2021Causal Inference Under Unmeasured Confounding With Negative Controls: A Minimax Learning Approachcited by 43
- 2022Provably Efficient Reinforcement Learning in Partially Observable Dynamical Systemscited by 35
- 2021A Minimax Learning Approach to Off-Policy Evaluation in Confounded Partially Observable Markov Decision Processescited by 34
- 2024Applied Causal Inference Powered by ML and AIcited by 30
- 2022Long-term Causal Inference Under Persistent Confounding via Data Combinationcited by 27
- 2021Proximal Learning for Individualized Treatment Regimes Under Unmeasured Confoundingcited by 21
- 2021Minimax Kernel Machine Learning for a Class of Doubly Robust Functionals with Application to Proximal Causal Inferencecited by 20
- 2022Future-Dependent Value-Based Off-Policy Evaluation in POMDPscited by 20
- 2022An Instrumental Variable Approach to Confounded Off-Policy Evaluationcited by 20
- 2022Estimating individual treatment effects under unobserved confounding using binary instrumentscited by 17
- 2022Deep Learning Methods for Proximal Inference via Maximum Moment Restrictioncited by 13
- 2023Minimax Instrumental Variable Regression and L2 Convergence Guarantees without Identification or Closednesscited by 13
12 most cited of 53 All 53 (JSON)
- 2026Proximal Balancing for Causal Effect Estimation under Unmeasured Confounding30 Sep 2026
- 2026Proximal Mediation Analysis with Hidden Recanting Witnesses16 Jun 2026
- 2026Decision-Aware Proximal Bridge Learning for Optimal Treatment Selection16 May 2026
- 2026Proximal Path-Specific Inference10 May 2026
- 2026Nonparametric Instrumental Variable Analysis Without Structural Equations: Debiased Inference on Functionals of Inverse Problems with No Solutions27 Apr 2026
- 2026Adaptive Estimation and Inference in Conditional Moment Models via the Discrepancy Principle2 Mar 2026
- 2025Comparing Two Proxy Methods for Causal Identification28 Nov 2025
- 2025Front-door Reducibility: Reducing ADMGs to the Standard Front-door Setting via a Graphical Criterion19 Nov 2025
- 2025Transferring Causal Effects using Proxies29 Oct 2025
- 2025Coupling Generative Modeling and an Autoencoder with the Causal Bridge29 Sep 2025
- 2025Causal Effect Identification in lvLiNGAM from Higher-Order Cumulants5 Jun 2025
- 2025Learning Treatment Representations for Downstream Instrumental Variable Regression2 Jun 2025
12 newest of 53 All 53 (JSON)