Deep Learning Based Brain Tumor Segmentation: A Survey
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Abstract (arXiv)
Brain tumor segmentation is one of the most challenging problems in medical image analysis. The goal of brain tumor segmentation is to generate accurate delineation of brain tumor regions. In recent years, deep learning methods have shown promising performance in solving various computer vision problems, such as image classification, object detection and semantic segmentation. A number of deep learning based methods have been applied to brain tumor segmentation and achieved promising results. Considering the remarkable breakthroughs made by state-of-the-art technologies, we use this survey to provide a comprehensive study of recently developed deep learning based brain tumor segmentation techniques. More than 100 scientific papers are selected and discussed in this survey, extensively covering technical aspects such as network architecture design, segmentation under imbalanced conditions, and multi-modality processes. We also provide insightful discussions for future development directions.
Key facts. Cited by 30 papers in the map (data through 7 Oct 2026). First posted on arXiv 18 Jul 2020.
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Citing papers per year: 2022: 4; 2023: 4; 2024: 5; 2025: 7; 2026: 10.
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- 2022CKD-TransBTS: Clinical Knowledge-Driven Hybrid Transformer with Modality-Correlated Cross-Attention for Brain Tumor Segmentationcited by 24
- 2024A Comprehensive Survey of Convolutions in Deep Learning: Applications, Challenges, and Future Trendscited by 16
- 2025Rethinking Brain Tumor Segmentation from the Frequency Domain Perspectivecited by 9
- 2024Transformers-based architectures for stroke segmentation: A reviewcited by 5
- 20223D Brain and Heart Volume Generative Models: A Surveycited by 4
- 2026BrainDINO: A Brain MRI Foundation Model for Generalizable Clinical Representation Learningcited by 4
- 2022Quantifying U-Net Uncertainty in Multi-Parametric MRI-based Glioma Segmentation by Spherical Image Projectioncited by 3
- 2023HALOS: Hallucination-free Organ Segmentation after Organ Resection Surgerycited by 3
- 2025Self-Supervised Learning for Image Segmentation: A Comprehensive Surveycited by 3
- 2025Bridging the Perception-Cognition Gap:Re-engineering SAM2 with Hilbert-Mamba for Robust VLM-based Medical Diagnosiscited by 3
- 2022Suggestive Annotation of Brain MR Images with Gradient-guided Samplingcited by 2
- 2024Exploring the Relationship: Transformative Adaptive Activation Functions in Comparison to Other Activation Functionscited by 1
18 more
- 2026InfiltrNet: Dual-Branch CNN-Transformer Architecture for Brain Tumor Infiltration Risk Predictioncited by 1
- 2023Unsupervised Domain Adaptation for Medical Image Segmentation via Feature-space Density Matchingcited by 0
- 2023A Novel SLCA-UNet Architecture for Automatic MRI Brain Tumor Segmentationcited by 0
- 2023Contrastive Deep Encoding Enables Uncertainty-aware Machine-learning-assisted Histopathologycited by 0
- 2024Comparative Analysis of Image Enhancement Techniques for Brain Tumor Segmentation: Contrast, Histogram, and Hybrid Approachescited by 0
- 2024Neuro-TransUNet: Segmentation of stroke lesion in MRI using transformerscited by 0
- 2025Brain Tumor Identification using Improved YOLOv8cited by 0
- 2025BrainSegDMlF: A Dynamic Fusion-enhanced SAM for Brain Lesion Segmentationcited by 0
- 2025Validation of Various Normalization Methods for Brain Tumor Segmentation: Can Federated Learning Overcome This Heterogeneity?cited by 0
- 2025Novel Deep Learning Architectures for Classification and Segmentation of Brain Tumors from MRI Imagescited by 0
- 2026Single-Slice-to-3D Reconstruction in Medical Imaging and Natural Objects: A Comparative Benchmark with SAM 3Dcited by 0
- 2026Brain Tumor Segmentation with Special Emphasis on the Non-Enhancing Brain Tumor Compartmentcited by 0
- 2026Bridging visual saliency and large language models for explainable deep learning in medical imagingcited by 0
- 2026D3Seg: Dependency-Aware Diffusion for Brain Tumor Segmentation with Missing Modalitiescited by 0
- 2026A Novel Global Context-aware Deep Neural Network for Enhanced Brain Tumor Segmentation using Magnetic Resonance Imagescited by 0
- 2026CoMNet: A MedNeXt-CorrDiff Framework for Multi-Site Brain Tumor Segmentationcited by 0
- 2026RUFNet: Query-Guided Support Mask Refinement and Uncertainty Fusion based on Hybrid Mamba for Few-Shot Brain Tumor Segmentationcited by 0
- 2026Lightweight Vision Transformer-Based U-Net for Brain Tumor Segmentation from MRIcited by 0
- 2026Lightweight Vision Transformer-Based U-Net for Brain Tumor Segmentation from MRI24 Sep 2026
- 2026RUFNet: Query-Guided Support Mask Refinement and Uncertainty Fusion based on Hybrid Mamba for Few-Shot Brain Tumor Segmentation6 Jul 2026
- 2026CoMNet: A MedNeXt-CorrDiff Framework for Multi-Site Brain Tumor Segmentation13 Jun 2026
- 2026A Novel Global Context-aware Deep Neural Network for Enhanced Brain Tumor Segmentation using Magnetic Resonance Images28 May 2026
- 2026D3Seg: Dependency-Aware Diffusion for Brain Tumor Segmentation with Missing Modalities21 May 2026
- 2026Bridging visual saliency and large language models for explainable deep learning in medical imaging7 May 2026
- 2026InfiltrNet: Dual-Branch CNN-Transformer Architecture for Brain Tumor Infiltration Risk Prediction4 May 2026
- 2026BrainDINO: A Brain MRI Foundation Model for Generalizable Clinical Representation Learning30 Apr 2026
- 2026Brain Tumor Segmentation with Special Emphasis on the Non-Enhancing Brain Tumor Compartment25 Feb 2026
- 2026Single-Slice-to-3D Reconstruction in Medical Imaging and Natural Objects: A Comparative Benchmark with SAM 3D10 Feb 2026
- 2025Bridging the Perception-Cognition Gap:Re-engineering SAM2 with Hilbert-Mamba for Robust VLM-based Medical Diagnosis30 Dec 2025
- 2025Novel Deep Learning Architectures for Classification and Segmentation of Brain Tumors from MRI Images6 Dec 2025
18 more
- 2025Validation of Various Normalization Methods for Brain Tumor Segmentation: Can Federated Learning Overcome This Heterogeneity?8 Oct 2025
- 2025Rethinking Brain Tumor Segmentation from the Frequency Domain Perspective11 Jun 2025
- 2025Self-Supervised Learning for Image Segmentation: A Comprehensive Survey19 May 2025
- 2025BrainSegDMlF: A Dynamic Fusion-enhanced SAM for Brain Lesion Segmentation9 May 2025
- 2025Brain Tumor Identification using Improved YOLOv86 Feb 2025
- 2024Neuro-TransUNet: Segmentation of stroke lesion in MRI using transformers10 Jun 2024
- 2024Comparative Analysis of Image Enhancement Techniques for Brain Tumor Segmentation: Contrast, Histogram, and Hybrid Approaches8 Apr 2024
- 2024Transformers-based architectures for stroke segmentation: A review27 Mar 2024
- 2024A Comprehensive Survey of Convolutions in Deep Learning: Applications, Challenges, and Future Trends23 Feb 2024
- 2024Exploring the Relationship: Transformative Adaptive Activation Functions in Comparison to Other Activation Functions14 Feb 2024
- 2023Contrastive Deep Encoding Enables Uncertainty-aware Machine-learning-assisted Histopathology13 Sep 2023
- 2023A Novel SLCA-UNet Architecture for Automatic MRI Brain Tumor Segmentation16 Jul 2023
- 2023Unsupervised Domain Adaptation for Medical Image Segmentation via Feature-space Density Matching9 May 2023
- 2023HALOS: Hallucination-free Organ Segmentation after Organ Resection Surgery14 Mar 2023
- 2022Quantifying U-Net Uncertainty in Multi-Parametric MRI-based Glioma Segmentation by Spherical Image Projection12 Oct 2022
- 20223D Brain and Heart Volume Generative Models: A Survey12 Oct 2022
- 2022CKD-TransBTS: Clinical Knowledge-Driven Hybrid Transformer with Modality-Correlated Cross-Attention for Brain Tumor Segmentation15 Jul 2022
- 2022Suggestive Annotation of Brain MR Images with Gradient-guided Sampling2 Jun 2022
- 2022CKD-TransBTS: Clinical Knowledge-Driven Hybrid Transformer with Modality-Correlated Cross-Attention for Brain Tumor Segmentationcited by 24
- 2024A Comprehensive Survey of Convolutions in Deep Learning: Applications, Challenges, and Future Trendscited by 16
- 2025Rethinking Brain Tumor Segmentation from the Frequency Domain Perspectivecited by 9
- 2024Transformers-based architectures for stroke segmentation: A reviewcited by 5
- 20223D Brain and Heart Volume Generative Models: A Surveycited by 4
- 2026BrainDINO: A Brain MRI Foundation Model for Generalizable Clinical Representation Learningcited by 4
- 2022Quantifying U-Net Uncertainty in Multi-Parametric MRI-based Glioma Segmentation by Spherical Image Projectioncited by 3
- 2023HALOS: Hallucination-free Organ Segmentation after Organ Resection Surgerycited by 3
- 2025Self-Supervised Learning for Image Segmentation: A Comprehensive Surveycited by 3
- 2022Suggestive Annotation of Brain MR Images with Gradient-guided Samplingcited by 2
- 2024Exploring the Relationship: Transformative Adaptive Activation Functions in Comparison to Other Activation Functionscited by 1
- 2026InfiltrNet: Dual-Branch CNN-Transformer Architecture for Brain Tumor Infiltration Risk Predictioncited by 1
12 most cited of 28 All 28 (JSON)
- 2026Lightweight Vision Transformer-Based U-Net for Brain Tumor Segmentation from MRI24 Sep 2026
- 2026CoMNet: A MedNeXt-CorrDiff Framework for Multi-Site Brain Tumor Segmentation13 Jun 2026
- 2026A Novel Global Context-aware Deep Neural Network for Enhanced Brain Tumor Segmentation using Magnetic Resonance Images28 May 2026
- 2026D3Seg: Dependency-Aware Diffusion for Brain Tumor Segmentation with Missing Modalities21 May 2026
- 2026Bridging visual saliency and large language models for explainable deep learning in medical imaging7 May 2026
- 2026InfiltrNet: Dual-Branch CNN-Transformer Architecture for Brain Tumor Infiltration Risk Prediction4 May 2026
- 2026BrainDINO: A Brain MRI Foundation Model for Generalizable Clinical Representation Learning30 Apr 2026
- 2026Brain Tumor Segmentation with Special Emphasis on the Non-Enhancing Brain Tumor Compartment25 Feb 2026
- 2026Single-Slice-to-3D Reconstruction in Medical Imaging and Natural Objects: A Comparative Benchmark with SAM 3D10 Feb 2026
- 2025Novel Deep Learning Architectures for Classification and Segmentation of Brain Tumors from MRI Images6 Dec 2025
- 2025Validation of Various Normalization Methods for Brain Tumor Segmentation: Can Federated Learning Overcome This Heterogeneity?8 Oct 2025
- 2025Rethinking Brain Tumor Segmentation from the Frequency Domain Perspective11 Jun 2025
12 newest of 28 All 28 (JSON)