Weakly Supervised Lesion Localization With Probabilistic-CAM Pooling
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Abstract (arXiv)
Localizing thoracic diseases on chest X-ray plays a critical role in clinical practices such as diagnosis and treatment planning. However, current deep learning based approaches often require strong supervision, e.g. annotated bounding boxes, for training such systems, which is infeasible to harvest in large-scale. We present Probabilistic Class Activation Map (PCAM) pooling, a novel global pooling operation for lesion localization with only image-level supervision. PCAM pooling explicitly leverages the excellent localization ability of CAM during training in a probabilistic fashion. Experiments on the ChestX-ray14 dataset show a ResNet-34 model trained with PCAM pooling outperforms state-of-the-art baselines on both the classification task and the localization task. Visual examination on the probability maps generated by PCAM pooling shows clear and sharp boundaries around lesion regions compared to the localization heatmaps generated by CAM. PCAM pooling is open sourced at https://github.com/jfhealthcare/Chexpert.
Key facts. Cited by 35 papers in the map (data through 7 Oct 2026). First posted on arXiv 29 May 2020.
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Citing papers per year: 2021: 11; 2022: 8; 2023: 4; 2024: 6; 2025: 3; 2026: 3.
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- 2021TorchXRayVision: A library of chest X-ray datasets and modelscited by 131
- 2023ChatCAD: Interactive Computer-Aided Diagnosis on Medical Image using Large Language Modelscited by 116
- 2022Preserving Privacy in Federated Learning with Ensemble Cross-Domain Knowledge Distillationcited by 45
- 2024Modeling Caption Diversity in Contrastive Vision-Language Pretrainingcited by 42
- 2023ChatCAD+: Towards a Universal and Reliable Interactive CAD using LLMscited by 35
- 2022Transforming medical imaging with Transformers? A comparative review of key properties, current progresses, and future perspectivescited by 32
- 2021VisualCheXbert: Addressing the Discrepancy Between Radiology Report Labels and Image Labelscited by 27
- 2021Vision Transformer using Low-level Chest X-ray Feature Corpus for COVID-19 Diagnosis and Severity Quantificationcited by 21
- 2021Federated Split Vision Transformer for COVID-19 CXR Diagnosis using Task-Agnostic Trainingcited by 17
- 2022AI can evolve without labels: self-evolving vision transformer for chest X-ray diagnosis through knowledge distillationcited by 17
- 2021Vision Transformer for COVID-19 CXR Diagnosis using Chest X-ray Feature Corpuscited by 12
- 2025RadAlign: Advancing Radiology Report Generation with Vision-Language Concept Alignmentcited by 12
23 more
- 2022Multi-Task Distributed Learning using Vision Transformer with Random Patch Permutationcited by 10
- 2023Inherently Interpretable Multi-Label Classification Using Class-Specific Counterfactualscited by 10
- 2025MMXU: A Multi-Modal and Multi-X-ray Understanding Dataset for Disease Progressioncited by 9
- 2022Federated Learning with Privacy-Preserving Ensemble Attention Distillationcited by 6
- 2021Weakly Supervised Thoracic Disease Localization via Disease Maskscited by 5
- 2022ThoraX-PriorNet: A Novel Attention-Based Architecture Using Anatomical Prior Probability Maps for Thoracic Disease Classificationcited by 5
- 2024Can we Constrain Concept Bottleneck Models to Learn Semantically Meaningful Input Features?cited by 4
- 2021Gifsplanation via Latent Shift: A Simple Autoencoder Approach to Counterfactual Generation for Chest X-rayscited by 2
- 2021Many-to-One Distribution Learning and K-Nearest Neighbor Smoothing for Thoracic Disease Identificationcited by 2
- 2021Severity Quantification and Lesion Localization of COVID-19 on CXR using Vision Transformercited by 2
- 2021Image Embedding and Model Ensembling for Automated Chest X-Ray Interpretationcited by 2
- 2022Understanding Transfer Learning for Chest Radiograph Clinical Report Generation with Modified Transformer Architecturescited by 1
- 2024Secure Federated Learning Approaches to Diagnosing COVID-19cited by 1
- 2024Category-wise Fine-Tuning: Resisting Incorrect Pseudo-Labels in Multi-Label Image Classification with Partial Labelscited by 1
- 2024Attri-Net: A Globally and Locally Inherently Interpretable Model for Multi-Label Classification Using Class-Specific Counterfactualscited by 1
- 2026CXR-LT 2026 Challenge: Projection-Aware Multi-Label and Zero-Shot Chest X-Ray Classificationcited by 1
- 2021Chest X-Rays Image Classification from beta-Variational Autoencoders Latent Featurescited by 0
- 2022CDNet: Contrastive Disentangled Network for Fine-Grained Image Categorization of Ocular B-Scan Ultrasoundcited by 0
- 2023Multi-Scale Feature Fusion using Parallel-Attention Block for COVID-19 Chest X-ray Diagnosiscited by 0
- 2024More Than Positive and Negative: Communicating Fine Granularity in Medical Diagnosiscited by 0
- 2025Deep Learning-Based Breast Cancer Detection in Mammography: A Multi-Center Validation Study in Thai Populationcited by 0
- 2026From Classification to Localization and Clinical Validation: Large-Scale Development of a Deep Learning System for Thoracic Disease Detection on Chest Radiographs in Thailandcited by 0
- 2026From Image Interpretation to Clinical Reasoning: Upstream Physician-Context-Aware Multimodal Learning with Causal Reinforcement Learningcited by 0
- 2026From Image Interpretation to Clinical Reasoning: Upstream Physician-Context-Aware Multimodal Learning with Causal Reinforcement Learning30 Sep 2026
- 2026From Classification to Localization and Clinical Validation: Large-Scale Development of a Deep Learning System for Thoracic Disease Detection on Chest Radiographs in Thailand10 Jul 2026
- 2026CXR-LT 2026 Challenge: Projection-Aware Multi-Label and Zero-Shot Chest X-Ray Classification2 Apr 2026
- 2025Deep Learning-Based Breast Cancer Detection in Mammography: A Multi-Center Validation Study in Thai Population29 May 2025
- 2025MMXU: A Multi-Modal and Multi-X-ray Understanding Dataset for Disease Progression17 Feb 2025
- 2025RadAlign: Advancing Radiology Report Generation with Vision-Language Concept Alignment13 Jan 2025
- 2024More Than Positive and Negative: Communicating Fine Granularity in Medical Diagnosis5 Aug 2024
- 2024Attri-Net: A Globally and Locally Inherently Interpretable Model for Multi-Label Classification Using Class-Specific Counterfactuals8 Jun 2024
- 2024Modeling Caption Diversity in Contrastive Vision-Language Pretraining30 Apr 2024
- 2024Can we Constrain Concept Bottleneck Models to Learn Semantically Meaningful Input Features?1 Feb 2024
- 2024Category-wise Fine-Tuning: Resisting Incorrect Pseudo-Labels in Multi-Label Image Classification with Partial Labels30 Jan 2024
- 2024Secure Federated Learning Approaches to Diagnosing COVID-1923 Jan 2024
23 more
- 2023ChatCAD+: Towards a Universal and Reliable Interactive CAD using LLMs25 May 2023
- 2023Multi-Scale Feature Fusion using Parallel-Attention Block for COVID-19 Chest X-ray Diagnosis25 Apr 2023
- 2023Inherently Interpretable Multi-Label Classification Using Class-Specific Counterfactuals1 Mar 2023
- 2023ChatCAD: Interactive Computer-Aided Diagnosis on Medical Image using Large Language Models14 Feb 2023
- 2022Federated Learning with Privacy-Preserving Ensemble Attention Distillation16 Oct 2022
- 2022ThoraX-PriorNet: A Novel Attention-Based Architecture Using Anatomical Prior Probability Maps for Thoracic Disease Classification6 Oct 2022
- 2022Preserving Privacy in Federated Learning with Ensemble Cross-Domain Knowledge Distillation10 Sep 2022
- 2022CDNet: Contrastive Disentangled Network for Fine-Grained Image Categorization of Ocular B-Scan Ultrasound17 Jun 2022
- 2022Transforming medical imaging with Transformers? A comparative review of key properties, current progresses, and future perspectives2 Jun 2022
- 2022Understanding Transfer Learning for Chest Radiograph Clinical Report Generation with Modified Transformer Architectures5 May 2022
- 2022Multi-Task Distributed Learning using Vision Transformer with Random Patch Permutation7 Apr 2022
- 2022AI can evolve without labels: self-evolving vision transformer for chest X-ray diagnosis through knowledge distillation13 Feb 2022
- 2021Federated Split Vision Transformer for COVID-19 CXR Diagnosis using Task-Agnostic Training2 Nov 2021
- 2021TorchXRayVision: A library of chest X-ray datasets and models31 Oct 2021
- 2021Chest X-Rays Image Classification from beta-Variational Autoencoders Latent Features29 Sep 2021
- 2021Image Embedding and Model Ensembling for Automated Chest X-Ray Interpretation5 May 2021
- 2021Vision Transformer using Low-level Chest X-ray Feature Corpus for COVID-19 Diagnosis and Severity Quantification15 Apr 2021
- 2021Severity Quantification and Lesion Localization of COVID-19 on CXR using Vision Transformer12 Mar 2021
- 2021Vision Transformer for COVID-19 CXR Diagnosis using Chest X-ray Feature Corpus12 Mar 2021
- 2021Many-to-One Distribution Learning and K-Nearest Neighbor Smoothing for Thoracic Disease Identification26 Feb 2021
- 2021VisualCheXbert: Addressing the Discrepancy Between Radiology Report Labels and Image Labels23 Feb 2021
- 2021Gifsplanation via Latent Shift: A Simple Autoencoder Approach to Counterfactual Generation for Chest X-rays18 Feb 2021
- 2021Weakly Supervised Thoracic Disease Localization via Disease Masks25 Jan 2021
- 2021TorchXRayVision: A library of chest X-ray datasets and modelscited by 131
- 2023ChatCAD: Interactive Computer-Aided Diagnosis on Medical Image using Large Language Modelscited by 116
- 2022Preserving Privacy in Federated Learning with Ensemble Cross-Domain Knowledge Distillationcited by 45
- 2023ChatCAD+: Towards a Universal and Reliable Interactive CAD using LLMscited by 35
- 2022Transforming medical imaging with Transformers? A comparative review of key properties, current progresses, and future perspectivescited by 32
- 2021VisualCheXbert: Addressing the Discrepancy Between Radiology Report Labels and Image Labelscited by 27
- 2021Vision Transformer using Low-level Chest X-ray Feature Corpus for COVID-19 Diagnosis and Severity Quantificationcited by 21
- 2021Federated Split Vision Transformer for COVID-19 CXR Diagnosis using Task-Agnostic Trainingcited by 17
- 2022AI can evolve without labels: self-evolving vision transformer for chest X-ray diagnosis through knowledge distillationcited by 17
- 2021Vision Transformer for COVID-19 CXR Diagnosis using Chest X-ray Feature Corpuscited by 12
- 2025RadAlign: Advancing Radiology Report Generation with Vision-Language Concept Alignmentcited by 12
- 2022Multi-Task Distributed Learning using Vision Transformer with Random Patch Permutationcited by 10
12 most cited of 32 All 32 (JSON)
- 2026From Classification to Localization and Clinical Validation: Large-Scale Development of a Deep Learning System for Thoracic Disease Detection on Chest Radiographs in Thailand10 Jul 2026
- 2026CXR-LT 2026 Challenge: Projection-Aware Multi-Label and Zero-Shot Chest X-Ray Classification2 Apr 2026
- 2025Deep Learning-Based Breast Cancer Detection in Mammography: A Multi-Center Validation Study in Thai Population29 May 2025
- 2025RadAlign: Advancing Radiology Report Generation with Vision-Language Concept Alignment13 Jan 2025
- 2024More Than Positive and Negative: Communicating Fine Granularity in Medical Diagnosis5 Aug 2024
- 2024Attri-Net: A Globally and Locally Inherently Interpretable Model for Multi-Label Classification Using Class-Specific Counterfactuals8 Jun 2024
- 2024Can we Constrain Concept Bottleneck Models to Learn Semantically Meaningful Input Features?1 Feb 2024
- 2024Category-wise Fine-Tuning: Resisting Incorrect Pseudo-Labels in Multi-Label Image Classification with Partial Labels30 Jan 2024
- 2024Secure Federated Learning Approaches to Diagnosing COVID-1923 Jan 2024
- 2023ChatCAD+: Towards a Universal and Reliable Interactive CAD using LLMs25 May 2023
- 2023Multi-Scale Feature Fusion using Parallel-Attention Block for COVID-19 Chest X-ray Diagnosis25 Apr 2023
- 2023Inherently Interpretable Multi-Label Classification Using Class-Specific Counterfactuals1 Mar 2023
12 newest of 32 All 32 (JSON)