Rapid Whole-Heart CMR with Single Volume Super-resolution

Background: Three-dimensional, whole heart, balanced steady state free precession (WH-bSSFP) sequences provide delineation of intra-cardiac and vascular anatomy. However, they have long acquisition times. Here, we propose significant speed ups using a deep learning single volume super resolution reconstruction, to recover high resolution features from rapidly acquired low resolution WH-bSSFP images. Methods: A 3D residual U-Net was trained using synthetic data, created from a library of high-resolution WH-bSSFP images by simulating 0.5 slice resolution and 0.5 phase resolution. The trained network was validated with synthetic test data, as well as prospective low-resolution data. Results: Synthetic low-resolution data had significantly better image quality after super-resolution reconstruction. Qualitative image scores showed super-resolved images had better edge sharpness, fewer residual artefacts and less image distortion than low-resolution images, with similar scores to high-resolution data. Quantitative image scores showed super-resolved images had significantly better edge sharpness than low-resolution or high-resolution images, with significantly better signal-to-noise ratio than high-resolution data. Vessel diameters measurements showed over-estimation in the low-resolution measurements, compared to the high-resolution data. No significant differences and no bias was found in the super-resolution measurements. Conclusion: This paper demonstrates the potential of using a residual U-Net for super-resolution reconstruction of rapidly acquired low-resolution whole heart bSSFP data within a clinical setting. The resulting network can be applied very quickly, making these techniques particularly appealing within busy clinical workflow. Thus, we believe that this technique may help speed up whole heart CMR in clinical practice.