OpenBioLink: A benchmarking framework for large-scale biomedical link prediction
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Abstract (arXiv)
SUMMARY: Recently, novel machine-learning algorithms have shown potential for predicting undiscovered links in biomedical knowledge networks. However, dedicated benchmarks for measuring algorithmic progress have not yet emerged. With OpenBioLink, we introduce a large-scale, high-quality and highly challenging biomedical link prediction benchmark to transparently and reproducibly evaluate such algorithms. Furthermore, we present preliminary baseline evaluation results. AVAILABILITY AND IMPLEMENTATION: Source code, data and supplementary files are openly available at https://github.com/OpenBioLink/OpenBioLink CONTACT: matthias.samwald ((at)) meduniwien.ac.at
Key facts. Cited by 28 papers in the map (data through 14 Oct 2026). First posted on arXiv 10 Dec 2019.
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Citing papers per year: 2021: 6; 2022: 3; 2023: 9; 2024: 5; 2025: 3; 2026: 2.
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- 2022A Survey of Knowledge Graph Reasoning on Graph Types: Static, Dynamic, and Multimodalcited by 106
- 2021A Review of Biomedical Datasets Relating to Drug Discovery: A Knowledge Graph Perspectivecited by 38
- 2021Understanding the Performance of Knowledge Graph Embeddings in Drug Discoverycited by 18
- 2022Positive-Unlabeled Learning with Adversarial Data Augmentation for Knowledge Graph Completioncited by 13
- 2025Graph Neural Networks in Modern AI-aided Drug Discoverycited by 12
- 2021A curated, ontology-based, large-scale knowledge graph of artificial intelligence tasks and benchmarkscited by 11
- 2021Implications of Topological Imbalance for Representation Learning on Biomedical Knowledge Graphscited by 11
- 2023An Open-Source Knowledge Graph Ecosystem for the Life Sciencescited by 11
- 2023Comprehensive evaluation of deep and graph learning on drug-drug interactions predictioncited by 10
- 2023Accurate and interpretable drug-drug interaction prediction enabled by knowledge subgraph learningcited by 9
- 2021Explainable Biomedical Recommendations via Reinforcement Learning Reasoning on Knowledge Graphscited by 7
- 2023Knowledge-augmented Graph Machine Learning for Drug Discovery: A Surveycited by 6
16 more
- 2025Biomedical Knowledge Graph: A Survey of Domains, Tasks, and Real-World Applicationscited by 6
- 2024MOTIVE: A Drug-Target Interaction Graph For Inductive Link Predictioncited by 5
- 2023Clinical Trial Recommendations Using Semantics-Based Inductive Inference and Knowledge Graph Embeddingscited by 4
- 2021Prediction of Adverse Biological Effects of Chemicals Using Knowledge Graph Embeddingscited by 2
- 2023Know2BIO: A Comprehensive Dual-View Benchmark for Evolving Biomedical Knowledge Graphscited by 2
- 2024TWIG: Towards pre-hoc Hyperparameter Optimisation and Cross-Graph Generalisation via Simulated KGE Modelscited by 2
- 2024The Role of Graph Topology in the Performance of Biomedical Knowledge Graph Completion Modelscited by 2
- 2024MARS: A neurosymbolic approach for interpretable drug discoverycited by 2
- 2023Decoding Virtual Healthcare Success through Knowledge-Aware and Multimodal Predictive Modelingcited by 1
- 2023Knowledge Graphs are not Created Equal: Exploring the Properties and Structure of Real KGscited by 1
- 2025On the Theoretical Limitations of Embedding-based Link Predictioncited by 1
- 2026Unifying biomedical knowledge in a modern multimodal graphcited by 1
- 2022OntoMerger: An Ontology Integration Library for Deduplicating and Connecting Knowledge Graph Nodescited by 0
- 2023A Review of Link Prediction Applications in Network Biologycited by 0
- 2024Improving rule mining via embedding-based link predictioncited by 0
- 2026THBKG: A Temporal Biomedical Knowledge Graph for Decision-Aligned Clinical Advancement Predictioncited by 0
- 2026THBKG: A Temporal Biomedical Knowledge Graph for Decision-Aligned Clinical Advancement Prediction6 Aug 2026
- 2026Unifying biomedical knowledge in a modern multimodal graph29 Apr 2026
- 2025On the Theoretical Limitations of Embedding-based Link Prediction27 Jun 2025
- 2025Graph Neural Networks in Modern AI-aided Drug Discovery7 Jun 2025
- 2025Biomedical Knowledge Graph: A Survey of Domains, Tasks, and Real-World Applications20 Jan 2025
- 2024MARS: A neurosymbolic approach for interpretable drug discovery2 Oct 2024
- 2024The Role of Graph Topology in the Performance of Biomedical Knowledge Graph Completion Models6 Sep 2024
- 2024Improving rule mining via embedding-based link prediction14 Jun 2024
- 2024MOTIVE: A Drug-Target Interaction Graph For Inductive Link Prediction12 Jun 2024
- 2024TWIG: Towards pre-hoc Hyperparameter Optimisation and Cross-Graph Generalisation via Simulated KGE Models8 Feb 2024
- 2023A Review of Link Prediction Applications in Network Biology3 Dec 2023
- 2023Accurate and interpretable drug-drug interaction prediction enabled by knowledge subgraph learning25 Nov 2023
16 more
- 2023Knowledge Graphs are not Created Equal: Exploring the Properties and Structure of Real KGs10 Nov 2023
- 2023Know2BIO: A Comprehensive Dual-View Benchmark for Evolving Biomedical Knowledge Graphs5 Oct 2023
- 2023Clinical Trial Recommendations Using Semantics-Based Inductive Inference and Knowledge Graph Embeddings27 Sep 2023
- 2023An Open-Source Knowledge Graph Ecosystem for the Life Sciences11 Jul 2023
- 2023Comprehensive evaluation of deep and graph learning on drug-drug interactions prediction8 Jun 2023
- 2023Decoding Virtual Healthcare Success through Knowledge-Aware and Multimodal Predictive Modeling6 Jun 2023
- 2023Knowledge-augmented Graph Machine Learning for Drug Discovery: A Survey16 Feb 2023
- 2022A Survey of Knowledge Graph Reasoning on Graph Types: Static, Dynamic, and Multimodal12 Dec 2022
- 2022OntoMerger: An Ontology Integration Library for Deduplicating and Connecting Knowledge Graph Nodes5 Jun 2022
- 2022Positive-Unlabeled Learning with Adversarial Data Augmentation for Knowledge Graph Completion2 May 2022
- 2021Implications of Topological Imbalance for Representation Learning on Biomedical Knowledge Graphs13 Dec 2021
- 2021Prediction of Adverse Biological Effects of Chemicals Using Knowledge Graph Embeddings8 Dec 2021
- 2021Explainable Biomedical Recommendations via Reinforcement Learning Reasoning on Knowledge Graphs20 Nov 2021
- 2021A curated, ontology-based, large-scale knowledge graph of artificial intelligence tasks and benchmarks4 Oct 2021
- 2021Understanding the Performance of Knowledge Graph Embeddings in Drug Discovery17 May 2021
- 2021A Review of Biomedical Datasets Relating to Drug Discovery: A Knowledge Graph Perspective19 Feb 2021
- 2022A Survey of Knowledge Graph Reasoning on Graph Types: Static, Dynamic, and Multimodalcited by 106
- 2021A Review of Biomedical Datasets Relating to Drug Discovery: A Knowledge Graph Perspectivecited by 38
- 2021Understanding the Performance of Knowledge Graph Embeddings in Drug Discoverycited by 18
- 2022Positive-Unlabeled Learning with Adversarial Data Augmentation for Knowledge Graph Completioncited by 13
- 2025Graph Neural Networks in Modern AI-aided Drug Discoverycited by 12
- 2021A curated, ontology-based, large-scale knowledge graph of artificial intelligence tasks and benchmarkscited by 11
- 2021Implications of Topological Imbalance for Representation Learning on Biomedical Knowledge Graphscited by 11
- 2023An Open-Source Knowledge Graph Ecosystem for the Life Sciencescited by 11
- 2023Comprehensive evaluation of deep and graph learning on drug-drug interactions predictioncited by 10
- 2023Accurate and interpretable drug-drug interaction prediction enabled by knowledge subgraph learningcited by 9
- 2021Explainable Biomedical Recommendations via Reinforcement Learning Reasoning on Knowledge Graphscited by 7
- 2023Knowledge-augmented Graph Machine Learning for Drug Discovery: A Surveycited by 6
12 most cited of 27 All 27 (JSON)
- 2026THBKG: A Temporal Biomedical Knowledge Graph for Decision-Aligned Clinical Advancement Prediction6 Aug 2026
- 2026Unifying biomedical knowledge in a modern multimodal graph29 Apr 2026
- 2025On the Theoretical Limitations of Embedding-based Link Prediction27 Jun 2025
- 2025Graph Neural Networks in Modern AI-aided Drug Discovery7 Jun 2025
- 2025Biomedical Knowledge Graph: A Survey of Domains, Tasks, and Real-World Applications20 Jan 2025
- 2024MARS: A neurosymbolic approach for interpretable drug discovery2 Oct 2024
- 2024The Role of Graph Topology in the Performance of Biomedical Knowledge Graph Completion Models6 Sep 2024
- 2024Improving rule mining via embedding-based link prediction14 Jun 2024
- 2024MOTIVE: A Drug-Target Interaction Graph For Inductive Link Prediction12 Jun 2024
- 2024TWIG: Towards pre-hoc Hyperparameter Optimisation and Cross-Graph Generalisation via Simulated KGE Models8 Feb 2024
- 2023A Review of Link Prediction Applications in Network Biology3 Dec 2023
- 2023Accurate and interpretable drug-drug interaction prediction enabled by knowledge subgraph learning25 Nov 2023
12 newest of 27 All 27 (JSON)