Deep Semantic Segmentation of Natural and Medical Images: A Review
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Abstract (arXiv)
The semantic image segmentation task consists of classifying each pixel of an image into an instance, where each instance corresponds to a class. This task is a part of the concept of scene understanding or better explaining the global context of an image. In the medical image analysis domain, image segmentation can be used for image-guided interventions, radiotherapy, or improved radiological diagnostics. In this review, we categorize the leading deep learning-based medical and non-medical image segmentation solutions into six main groups of deep architectural, data synthesis-based, loss function-based, sequenced models, weakly supervised, and multi-task methods and provide a comprehensive review of the contributions in each of these groups. Further, for each group, we analyze each variant of these groups and discuss the limitations of the current approaches and present potential future research directions for semantic image segmentation.
Key facts. Cited by 124 papers in the map (data through 7 Oct 2026). First posted on arXiv 16 Oct 2019.
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Citing papers per year: 2021: 17; 2022: 24; 2023: 34; 2024: 22; 2025: 23; 2026: 4.
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- 2022Medical Image Segmentation Review: The success of U-Netcited by 190
- 2022PIDNet: A Real-time Semantic Segmentation Network Inspired by PID Controllerscited by 84
- 2022Scene Graph Generation: A Comprehensive Surveycited by 73
- 2022Dense Cross-Query-and-Support Attention Weighted Mask Aggregation for Few-Shot Segmentationcited by 65
- 2021Common Limitations of Image Processing Metrics: A Picture Storycited by 58
- 2022Towards a Guideline for Evaluation Metrics in Medical Image Segmentationcited by 58
- 2023Understanding metric-related pitfalls in image analysis validationcited by 57
- 2021Towards Fewer Annotations: Active Learning via Region Impurity and Prediction Uncertainty for Domain Adaptive Semantic Segmentationcited by 56
- 2023Segment Anything Model (SAM) Enhanced Pseudo Labels for Weakly Supervised Semantic Segmentationcited by 53
- 2022Semi-supervised Semantic Segmentation with Prototype-based Consistency Regularizationcited by 50
- 2021Convolution-Free Medical Image Segmentation using Transformerscited by 49
- 2023CaraNet: Context Axial Reverse Attention Network for Segmentation of Small Medical Objectscited by 43
38 more
- 2023Loss Functions in the Era of Semantic Segmentation: A Survey and Outlookcited by 33
- 2023PhenoBench -- A Large Dataset and Benchmarks for Semantic Image Interpretation in the Agricultural Domaincited by 31
- 2022A Survey on Deep Learning for Skin Lesion Segmentationcited by 22
- 2023FECANet: Boosting Few-Shot Semantic Segmentation with Feature-Enhanced Context-Aware Networkcited by 22
- 2023From CNN to Transformer: A Review of Medical Image Segmentation Modelscited by 22
- 2023A Recent Survey of Vision Transformers for Medical Image Segmentationcited by 22
- 2021Medical Image Segmentation with Limited Supervision: A Review of Deep Network Modelscited by 21
- 2021Modality specific U-Net variants for biomedical image segmentation: A surveycited by 20
- 2021A survey on shape-constraint deep learning for medical image segmentationcited by 15
- 2021Style Mixing and Patchwise Prototypical Matching for One-Shot Unsupervised Domain Adaptive Semantic Segmentationcited by 15
- 2023Treasure in Distribution: A Domain Randomization based Multi-Source Domain Generalization for 2D Medical Image Segmentationcited by 14
- 2021Uncertainty-Aware Deep Co-training for Semi-supervised Medical Image Segmentationcited by 12
- 2023PrivImage: Differentially Private Synthetic Image Generation using Diffusion Models with Semantic-Aware Pretrainingcited by 12
- 2024Query-guided Prototype Evolution Network for Few-Shot Segmentationcited by 12
- 2024CSWin-UNet: Transformer UNet with Cross-Shaped Windows for Medical Image Segmentationcited by 12
- 2024Explainable AI (XAI) in Image Segmentation in Medicine, Industry, and Beyond: A Surveycited by 11
- 2024SGSeg: Enabling Text-free Inference in Language-guided Segmentation of Chest X-rays via Self-guidancecited by 11
- 2023Gradient-Semantic Compensation for Incremental Semantic Segmentationcited by 10
- 2024Development of Skip Connection in Deep Neural Networks for Computer Vision and Medical Image Analysis: A Surveycited by 10
- 2021A Quantitative Comparison of Epistemic Uncertainty Maps Applied to Multi-Class Segmentationcited by 9
- 2023MDViT: Multi-domain Vision Transformer for Small Medical Image Segmentation Datasetscited by 9
- 2022Unsupervised Foggy Scene Understanding via Self Spatial-Temporal Label Diffusioncited by 8
- 2022Mixed-UNet: Refined Class Activation Mapping for Weakly-Supervised Semantic Segmentation with Multi-scale Inferencecited by 7
- 2022Swinv2-Imagen: Hierarchical Vision Transformer Diffusion Models for Text-to-Image Generationcited by 7
- 2023Iterative Loop Method Combining Active and Semi-Supervised Learning for Domain Adaptive Semantic Segmentationcited by 7
- 2024Investigating the Quality of DermaMNIST and Fitzpatrick17k Dermatological Image Datasetscited by 7
- 2024Cs2K: Class-specific and Class-shared Knowledge Guidance for Incremental Semantic Segmentationcited by 7
- 2023Domain Adaptive Sim-to-Real Segmentation of Oropharyngeal Organs Towards Robot-assisted Intubationcited by 6
- 2023Segment Any Events via Weighted Adaptation of Pivotal Tokenscited by 5
- 2021Interactive Segmentation via Deep Learning and B-Spline Explicit Active Surfacescited by 4
- 2021Hypernet-Ensemble Learning of Segmentation Probability for Medical Image Segmentation with Ambiguous Labelscited by 4
- 2022Improving Classification Model Performance on Chest X-Rays through Lung Segmentationcited by 4
- 2022Automatic Fine-grained Glomerular Lesion Recognition in Kidney Pathologycited by 4
- 2022Semantic Segmentation of Fruits on Multi-sensor Fused Data in Natural Orchardscited by 4
- 2023Radio astronomical images object detection and segmentation: A benchmark on deep learning methodscited by 4
- 2023LSFSL: Leveraging Shape Information in Few-shot Learningcited by 4
- 2023DermSynth3D: Synthesis of in-the-wild Annotated Dermatology Imagescited by 4
- 2023Classification of White Blood Cells Using Machine and Deep Learning Models: A Systematic Reviewcited by 4
50 most cited of 124 All 124 (JSON)
- 2026Quality-Guided Semi-Supervised Learning for Medical Image Segmentation1 Jun 2026
- 2026Weight Group-wise Post-Training Quantization for Medical Foundation Model9 Apr 2026
- 2026Unifying VLM-Guided Flow Matching and Spectral Anomaly Detection for Interpretable Veterinary Diagnosis7 Apr 2026
- 2026Atomic Depth Estimation From Noisy Electron Microscopy Data Via Deep Learning20 Jan 2026
- 2025WDFFU-Mamba: A Wavelet-guided Dual-attention Feature Fusion Mamba for Breast Tumor Segmentation in Ultrasound Images19 Dec 2025
- 2025JoDiffusion: Jointly Diffusing Image with Pixel-Level Annotations for Semantic Segmentation Promotion15 Dec 2025
- 2025Robust Variational Model Based Tailored UNet: Leveraging Edge Detector and Mean Curvature for Improved Image Segmentation8 Dec 2025
- 2025HyM-UNet: Synergizing Local Texture and Global Context via Hybrid CNN-Mamba Architecture for Medical Image Segmentation22 Nov 2025
- 2025Geometry-Aware Cross Modal Alignment for Light Field-LiDAR Semantic Segmentation8 Oct 2025
- 2025Integrating Background Knowledge in Medical Semantic Segmentation with Logic Tensor Networks26 Sep 2025
- 2025MSA2-Net: Utilizing Self-Adaptive Convolution Module to Extract Multi-Scale Information in Medical Image Segmentation1 Sep 2025
- 2025OmniMRI: A Unified Vision--Language Foundation Model for Generalist MRI Interpretation24 Aug 2025
38 more
- 2025What Can We Learn from Inter-Annotator Variability in Skin Lesion Segmentation?12 Aug 2025
- 2025Shallow Features Matter: Hierarchical Memory with Heterogeneous Interaction for Unsupervised Video Object Segmentation30 Jul 2025
- 2025Object Recognition Datasets and Challenges: A Review30 Jul 2025
- 2025ConSeg: Contextual Backdoor Attack Against Semantic Segmentation26 Jul 2025
- 2025DiSCO-3D : Discovering and segmenting Sub-Concepts from Open-vocabulary queries in NeRF19 Jul 2025
- 2025Advancing Complex Wide-Area Scene Understanding with Hierarchical Coresets Selection17 Jul 2025
- 2025Out-of-distribution data supervision towards biomedical semantic segmentation16 Jul 2025
- 2025Self-supervised Representation Learning with Local Aggregation for Image-based Profiling17 Jun 2025
- 2025ConStyX: Content Style Augmentation for Generalizable Medical Image Segmentation12 Jun 2025
- 2025FPGA-Enabled Machine Learning Applications in Earth Observation: A Systematic Review4 Jun 2025
- 2025LangDAug: Langevin Data Augmentation for Multi-Source Domain Generalization in Medical Image Segmentation26 May 2025
- 2025Accelerating Volumetric Medical Image Annotation via Short-Long Memory SAM 23 May 2025
- 2025Flip Learning: Weakly Supervised Erase to Segment Nodules in Breast Ultrasound26 Mar 2025
- 2025EPEE: Towards Efficient and Effective Foundation Models in Biomedicine3 Mar 2025
- 2025Transfer Risk Map: Mitigating Pixel-level Negative Transfer in Medical Segmentation4 Feb 2025
- 2024SP 3 : Superpixel-propagated pseudo-label learning for weakly semi-supervised medical image segmentation18 Nov 2024
- 2024MamT4: Multi-view Attention Networks for Mammography Cancer Classification3 Nov 2024
- 2024Taming Mambas for Voxel Level 3D Medical Image Segmentation20 Oct 2024
- 2024TransResNet: Integrating the Strengths of ViTs and CNNs for High Resolution Medical Image Segmentation via Feature Grafting1 Oct 2024
- 2024Interactive 3D Segmentation for Primary Gross Tumor Volume in Oropharyngeal Cancer10 Sep 2024
- 2024Segmentation by Factorization: Unsupervised Semantic Segmentation for Pathology by Factorizing Foundation Model Features9 Sep 2024
- 2024SGSeg: Enabling Text-free Inference in Language-guided Segmentation of Chest X-rays via Self-guidance7 Sep 2024
- 2024MacFormer: Semantic Segmentation with Fine Object Boundaries11 Aug 2024
- 2024Biomedical Image Segmentation: A Systematic Literature Review of Deep Learning Based Object Detection Methods6 Aug 2024
- 2024Segmentation Style Discovery: Application to Skin Lesion Images5 Aug 2024
- 2024DDU-Net: A Domain Decomposition-Based CNN for High-Resolution Image Segmentation on Multiple GPUs31 Jul 2024
- 2024CSWin-UNet: Transformer UNet with Cross-Shaped Windows for Medical Image Segmentation25 Jul 2024
- 2024Cs2K: Class-specific and Class-shared Knowledge Guidance for Incremental Semantic Segmentation12 Jul 2024
- 2024Empowering Tuberculosis Screening with Explainable Self-Supervised Deep Neural Networks19 Jun 2024
- 2024Development of Skip Connection in Deep Neural Networks for Computer Vision and Medical Image Analysis: A Survey2 May 2024
- 2024Explainable AI (XAI) in Image Segmentation in Medicine, Industry, and Beyond: A Survey2 May 2024
- 2024Boosting Medical Image Segmentation Performance with Adaptive Convolution Layer17 Apr 2024
- 2024CT evaluation of 2D and 3D holistic deep learning methods for the volumetric segmentation of airway lesions12 Mar 2024
- 2024Query-guided Prototype Evolution Network for Few-Shot Segmentation11 Mar 2024
- 2024Feature boosting with efficient attention for scene parsing29 Feb 2024
- 2024Investigating the Quality of DermaMNIST and Fitzpatrick17k Dermatological Image Datasets25 Jan 2024
- 2024Phenotyping calcification in vascular tissues using artificial intelligence15 Jan 2024
- 2023Segment Any Events via Weighted Adaptation of Pivotal Tokens24 Dec 2023
50 newest of 124 All 124 (JSON)
- 2023PrivImage: Differentially Private Synthetic Image Generation using Diffusion Models with Semantic-Aware Pretrainingcited by 12
- 2022Swinv2-Imagen: Hierarchical Vision Transformer Diffusion Models for Text-to-Image Generationcited by 7
- 2025JoDiffusion: Jointly Diffusing Image with Pixel-Level Annotations for Semantic Segmentation Promotioncited by 4
- 2025JoDiffusion: Jointly Diffusing Image with Pixel-Level Annotations for Semantic Segmentation Promotion15 Dec 2025
- 2023PrivImage: Differentially Private Synthetic Image Generation using Diffusion Models with Semantic-Aware Pretraining19 Oct 2023
- 2022Swinv2-Imagen: Hierarchical Vision Transformer Diffusion Models for Text-to-Image Generation18 Oct 2022
- 2022Medical Image Segmentation Review: The success of U-Netcited by 190
- 2022PIDNet: A Real-time Semantic Segmentation Network Inspired by PID Controllerscited by 84
- 2022Scene Graph Generation: A Comprehensive Surveycited by 73
- 2022Dense Cross-Query-and-Support Attention Weighted Mask Aggregation for Few-Shot Segmentationcited by 65
- 2021Common Limitations of Image Processing Metrics: A Picture Storycited by 58
- 2022Towards a Guideline for Evaluation Metrics in Medical Image Segmentationcited by 58
- 2023Understanding metric-related pitfalls in image analysis validationcited by 57
- 2021Towards Fewer Annotations: Active Learning via Region Impurity and Prediction Uncertainty for Domain Adaptive Semantic Segmentationcited by 56
- 2023Segment Anything Model (SAM) Enhanced Pseudo Labels for Weakly Supervised Semantic Segmentationcited by 53
- 2022Semi-supervised Semantic Segmentation with Prototype-based Consistency Regularizationcited by 50
- 2021Convolution-Free Medical Image Segmentation using Transformerscited by 49
- 2023CaraNet: Context Axial Reverse Attention Network for Segmentation of Small Medical Objectscited by 43
12 most cited of 118 All 118 (JSON)
- 2026Quality-Guided Semi-Supervised Learning for Medical Image Segmentation1 Jun 2026
- 2026Weight Group-wise Post-Training Quantization for Medical Foundation Model9 Apr 2026
- 2026Unifying VLM-Guided Flow Matching and Spectral Anomaly Detection for Interpretable Veterinary Diagnosis7 Apr 2026
- 2026Atomic Depth Estimation From Noisy Electron Microscopy Data Via Deep Learning20 Jan 2026
- 2025Robust Variational Model Based Tailored UNet: Leveraging Edge Detector and Mean Curvature for Improved Image Segmentation8 Dec 2025
- 2025Geometry-Aware Cross Modal Alignment for Light Field-LiDAR Semantic Segmentation8 Oct 2025
- 2025Integrating Background Knowledge in Medical Semantic Segmentation with Logic Tensor Networks26 Sep 2025
- 2025MSA2-Net: Utilizing Self-Adaptive Convolution Module to Extract Multi-Scale Information in Medical Image Segmentation1 Sep 2025
- 2025OmniMRI: A Unified Vision--Language Foundation Model for Generalist MRI Interpretation24 Aug 2025
- 2025What Can We Learn from Inter-Annotator Variability in Skin Lesion Segmentation?12 Aug 2025
- 2025Shallow Features Matter: Hierarchical Memory with Heterogeneous Interaction for Unsupervised Video Object Segmentation30 Jul 2025
- 2025Object Recognition Datasets and Challenges: A Review30 Jul 2025
12 newest of 118 All 118 (JSON)