Text-Guided Medical Image Segmentation via Residual Aggregation and Dense Alignment Representations

Specifying segmentation targets with natural language provides flexible semantic conditioning for medical image segmentation. However, existing methods still struggle to reliably ground high-level textual semantics into accurate pixel-level spatial prompts, especially under low-contrast lesions, ambiguous boundaries, and visually similar anatomical contexts. In this paper, we propose RADAR (Residual Aggregation and Dense Alignment Representations), a parameter-efficient framework for text-guided medical image segmentation. RADAR explicitly decouples and synergizes the medical semantic anchoring capability of BiomedCLIP with the prompt-driven mask decoding ability of MedSAM2, while enabling low-cost task adaptation via LoRA. Specifically, Guided Residual Depth Aggregation adaptively aggregates cross-layer features under semantic guidance to alleviate delayed textual injection and deep semantic dilution. Structured Dense Representation Alignment leverages a frozen BiomedCLIP to construct crop-level target, boundary, and context anchors, improving the local discriminability of dense features and the reliability of automatic prompts. Multi-modal Prompt Generation further converts cross-modal semantic responses into composite text, point, and mask prompts for MedSAM2 decoding. Experiments on three public medical image segmentation datasets show that RADAR achieves competitive performance with only 0.74M trainable parameters, demonstrating its effectiveness in parameter-efficient adaptation, semantic grounding, and dense representation enhancement. The source code is available at https://github.com/JGuiidev/RADAR.