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CLIMB: A Clinical Multimorbidity Benchmark for Diagnosing Co-occurring Conditions through Multiturn Conversations

arXiv 2609.35462 ↗First posted 28 Sep 2026cs.LG cs.AI cs.CLcited by 0

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Abstract (arXiv)

Patients often have several co-occurring clinical conditions, and the findings needed to identify and disambiguate them emerge over the course of a consultation. Evaluating clinical reasoning in this setting requires both multi-turn interaction and multi-label diagnosis. We introduce CLIMB, a benchmark in which a doctor model interviews a simulated patient to recover a ground truth set of co-occurring clinical conditions. Cases are synthesized from clinical decision algorithms and diagnostic datasets, grounding multimorbid presentations in structured clinical knowledge. Across six frontier and open models, none recovers the exact set of conditions in more than 10% of interactive cases. Diagnostic performance declines when conditions co-occur, even when models receive the full clinical record and the true number of conditions. Interaction reduces performance further. In controlled experiments, models behave like single-hypothesis trackers: they anchor on the diagnosis suggested by the opening findings, keep questioning around it, and recover a second condition mainly when a finding in view points to it. Questioning them further does not complete the set but adds mostly wrong diagnoses. We formalise this pattern with a theoretical reference model of single-hypothesis tracking. The benchmark, generator, and evaluation code are available at https://anonymous.4open.science/r/CLIMB-8340.

Key facts. No citing papers in the map yet (data through 14 Oct 2026). Builds on 5 of its 40 references that are in the map. First posted on arXiv 28 Sep 2026.

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References · 5

  1. 2023MEDITRON-70B: Scaling Medical Pretraining for Large Language Modelscited by 274
  2. 2025Sequential Diagnosis with Language Modelscited by 60
  3. 2025ReasonBENCH: Benchmarking the (In)Stability of LLM Reasoningcited by 9
  4. 2026Information-seeking failures of large language models in agentic clinical reasoningcited by 3
  5. 2026MoBayes: A Modular Bayesian Framework for Separating Reasoning from Language in Conversational Clinical Decision Supportcited by 1

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