CLC-YOLO: A Compact Channel-Gated Prototype Network for Real-Time Leakage-Aware Breast Ultrasound Lesion Segmentation

Reliable breast ultrasound lesion segmentation requires accurate boundaries and evaluation that prevents patients or duplicate images from crossing data splits. We propose Channel Local Contrast (CLC), a compact refinement of the YOLO26 segmentation prototype head. CLC adds a fixed local high-pass residual controlled by 64 zero-initialized, bounded channel gates. Baseline and CLC were compared in five matched folds on each of four breast ultrasound datasets. BUS-BRA used patient-disjoint outer tests with separate inner validation. BUS-UCLM and BrEaST used patient-grouped validation folds; BUSI used duplicate-component groups because patient identifiers are unavailable. Group-macro Dice increased by 1.68, 3.11, 1.12, and 2.45 percentage points on BUS-BRA, BUS-UCLM, BUSI, and BrEaST, respectively. Only the BUS-BRA paired 95% confidence interval excluded zero. CLC adds 64 parameters and 0.0049 giga floating-point operations (GFLOPs). At 640 pixels, single-T4, batch-one, 16-bit floating-point (FP16) TensorRT graph times were 2.1478 ms for CLC and 2.0512 ms for baseline, excluding preprocessing and postprocessing. CLC increased group-macro Dice across all four datasets with a measured T4 forward-pass overhead of 0.0966 ms. Code: https://github.com/mfazrinizar/CLC-YOLO