Architecture-aware Robustness Evaluation of Explainable Deep Learning for Breast Cancer Diagnosis

Explainable Artificial Intelligence (XAI) has become essential in medical image analysis to ensure transparency of deep learning (DL)-based diagnostic systems. However, selecting appropriate XAI techniques for breast cancer recognition remains largely ad hoc, with limited systematic evaluation across different DL architectures. This study presents a systematic architecture-aware evaluation protocol to assess the effectiveness of nine widely used XAI techniques across four categories of DL models: very deep, lightweight, transformer-based and hybrid neural networks. The evaluation is conducted on a breast ultrasound dataset comprising 780 images using clinically aligned spatial metrics, including Pointing Game, Intersection over Union and Mean Coverage, to quantify agreement between generated explanations and expert-annotated lesion regions. Results indicate that explanation quality is primarily influenced by the interaction between model architecture and XAI method, rather than any single technique consistently outperforming others. Hybrid architectures produce more spatially coherent explanations, while lightweight and transformer-based models exhibit greater variability across methods. The findings show that no single technique generalises across architectures and evaluation criteria, emphasising the need for joint selection of DL models and XAI techniques. Explainability depends on both model design and explanation strategy and should not be considered independently. This work provides a structured evaluation protocol and practical guidance for selecting XAI techniques in breast cancer diagnosis, supporting more transparent clinical decision-support systems. textcolorblueCode is publicly available at https://github.com/Nishan-Charlie/Explainable-AI