PP-Net: A Hybrid Physical-Prior Neural Network for Scattered Light Removal in Biomedical Images on Embedded Devices

Scattered light is common in biomedical images, yet its removal remains challenging. The difficulty arises from three aspects: first, aligned scattered-light-free biomedical ground truth is often unavailable; second, scattering is coupled with weak illumination and sensor-induced noise; and third, many learning-based restoration models are computationally expensive for embedded devices in Internet of Medical Things (IoMT) scenarios. To address these issues, this paper proposes PP-Net, a hybrid physical-prior neural network for biomedical scattered light removal. The proposed method consists of three components: DFN-Net suppresses sensor-induced noise, ASAP estimates the scattering map and recovers a physics-based prior map, and GF-Net refines the prior map by fusing it with the denoised observation. To reduce the dependence on paired biomedical ground truth, a progressive synthetic training and cross-domain transfer strategy is developed. Experiments show that the physical-prior branch improves the peak signal-to-noise ratio (PSNR) by up to 1.26 dB on paired synthetic benchmarks. Under joint noise-and-scattering degradation, PP-Net improves PSNR by more than 10.8 dB and the structural similarity index measure (SSIM) by more than 0.62 compared with representative baseline methods. On real W2S biomedical images, the proposed method reduces the average Natural Image Quality Evaluator (NIQE) score by 43.3%. Edge deployment with RKNN conversion and INT8 quantization achieves an average inference latency of approximately 200 ms per 512×512 image over 360 test images. These results demonstrate that PP-Net provides an effective and deployable solution for microscopic imaging, endoscopic inspection, and edge-assisted biomedical analysis in IoMT scenarios.