A Physics-Conditioned Neural Operator for Generalization of Atrioventricular Valve Mechanics across Pressure and Tissue Properties

Mitral and tricuspid regurgitation are the most common regurgitant valvular lesions, yet only a minority of severe cases undergo corrective surgery. Rapid assessment of valve mechanics could enable earlier, more precise intervention, but finite element (FE) analysis is slow to repeat across the many loading and tissue-property values of interest, which for a given valve are not known in advance. We introduce the Physics-Conditioned Neural Operator (PCNO), a transformer-based neural operator predicting leaflet displacement, strain, and stress fields conditioned on systolic blood pressure and tissue properties. PCNO is trained on, and evaluated against, FEBio simulations of functional and regurgitant mitral and tricuspid valves and of three mitral pathologies. With pressure and all material parameters simultaneously outside the training support, displacement error against FE reaches 4.48% and the mean errors of unsupervised geometric measures of valve function stay within 3.5%, indicating a conditioned solution operator over parameter space rather than an interpolator of the training set. Under this shift, PCNO is also more accurate than graph neural network and graph neural operator baselines trained on the same simulations, with the largest margins in stress.