Encrypt What Matters: When Selective Homomorphic Inference Is Efficient

Fully homomorphic encryption (FHE) enables inference on private data without revealing it to the server, but evaluating an entire input under FHE is expensive. We study selective homomorphic inference, where only a sensitive region of interest (ROI) is encrypted, and computations independent of that region are performed in plaintext. Selective evaluation produces the same output as full FHE on the same model, without retraining. Its efficiency depends on how quickly encrypted dependencies spread through the network. For small encrypted ROIs, locality-preserving architectures can achieve order-of-magnitude homomorphic-evaluation speedups, whereas architectures with early global mixing provide essentially no speedup. These results identify locality as the key architectural property governing the benefit of selective homomorphic inference.