mlsanityData to 14 Oct 2026

Site Is Decodable Before Pretraining: Negative Controls for Probing Frozen Brain-MRI Foundation Models

arXiv 2608.10295 ↗First posted 10 Aug 2026cs.CV cs.AIcited by 1

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Abstract (arXiv)

Brain foundation models are often tested with a probe. The model is frozen, a simple classifier is trained on its output, and the classifier's accuracy is taken as a sign of what pretraining learned. We show that this reading can be wrong unless two controls are reported with it. We probed three frozen 3-D brain-MRI models at five depths, on two independent multi-site cohorts (ABIDE-I and ABIDE-II). The site where a scan was acquired could be predicted at about 0.9, on a scale where 0 is chance and 1 is perfect. No clinical or demographic target came close. An untrained copy of the same model predicted site just as well on both cohorts. Untrained models of three architectures, each built with three random seeds, did the same on ABIDE-I. The raw image, shrunk to 12x12x12 voxels and given to no model at all, predicted site at 0.95. Pretraining did not create the site signal. It was already in the scans. We also looked for any clinical target on which pretraining beats an untrained model, and found no reliable case. Adjusting for age, sex and diagnosis left site prediction almost unchanged, and so did a 4.6-fold increase in the number of voxels. Resting-state fMRI from the same people showed the same pattern. Site was the most predictable attribute of brain connectivity (0.81), and it survived five untrained layers while age did not. We recommend reporting two controls with every probe of a brain foundation model: running the probe again on the untrained model, and on the raw input. We release the code for both.

Key facts. Cited by 1 paper in the map (data through 14 Oct 2026). Builds on 15 of its 28 references that are in the map. First posted on arXiv 10 Aug 2026.

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15 of 28 references.

References · 15

  1. 2021On the Opportunities and Risks of Foundation Modelscited by 4,033
  2. 2020Shortcut Learning in Deep Neural Networkscited by 1,969
  3. 2016Understanding intermediate layers using linear classifier probescited by 1,353
  4. 2022Swin UNETR: Swin Transformers for Semantic Segmentation of Brain Tumors in MRI Imagescited by 830
  5. 2019Designing and Interpreting Probes with Control Taskscited by 640
  6. 2020Null It Out: Guarding Protected Attributes by Iterative Nullspace Projectioncited by 455
  7. 2021Self-Supervised Pre-Training of Swin Transformers for 3D Medical Image Analysiscited by 422
  8. 2021SynthSeg: Segmentation of brain MRI scans of any contrast and resolution without retrainingcited by 237
  9. 2021Reading Race: AI Recognises Patient's Racial Identity In Medical Imagescited by 156
  10. 2023On the Challenges and Perspectives of Foundation Models for Medical Image Analysiscited by 135
  11. 2024Brain-JEPA: Brain Dynamics Foundation Model with Gradient Positioning and Spatiotemporal Maskingcited by 65
  12. 2020Detect and Correct Bias in Multi-Site Neuroimaging Datasetscited by 45
3 more
  1. 2019Machine Learning with Multi-Site Imaging Data: An Empirical Study on the Impact of Scanner Effectscited by 43
  2. 2024BrainSegFounder: Towards 3D Foundation Models for Neuroimage Segmentationcited by 39
  3. 2019Scanner Invariant Representations for Diffusion MRI Harmonizationcited by 27

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