Do Pathology Vision-Language Models Truly See Pathology?
On the map: Multimodal LLMs / vision-language models → Medical vision-language models
Abstract (arXiv)
Pathology vision-language models (VLMs) have recently progressed rapidly and are commonly evaluated by answer accuracy on pathology VQA benchmarks. However, we dig into current evaluations and identify three overlooked issues: 1) Visual evidence is not always necessary. For instance, Gemini-3-Pro achieves 53.5% average accuracy across 5 VQA benchmarks without any visual input. 2) Domain training can improve accuracy without proportional gains in visual binding. Compared with Qwen2.5-VL-7B, Patho-R1-7B exhibits a 5.8-point lower multimodal gain and a 3.7-point lower attention IoU. 3) Entity-level attention is diffuse and weakly query-specific. On PathVG, attention maps remain highly correlated across different entity queries. These issues can lead to substantial misjudgments of pathology VLMs' actual multimodal capabilities. To this end, we present PathBind, a benchmark comprising 2,600 samples: PathBind-VQA with 1,500 questions across six dimensions, PathBind-PTA with 600 questions from a private pathology teaching atlas, and PathBind-Grounding with 500 expert-curated region-level samples. Each component undergoes task-specific automated filtering and expert review to reduce textual shortcuts and improve entity-region correspondence. We evaluate 18 representative VLMs on VQA samples of PathBind and five existing pathology VQA benchmarks, and further evaluate 10 VLMs on PathBind-Grounding and PathVG. Results show that current pathology VLMs still exhibit a substantial gap between answer-side performance and visual-semantic binding.
Key facts. Cited by 2 papers in the map (data through 7 Oct 2026). Placed in Medical vision-language models, one of 16 directions in Multimodal LLMs / vision-language models. Builds on 19 of its 33 references that are in the map. First posted on arXiv 23 Jul 2026.
Builds on
19 of 33 references.
Closest ancestors · 7
Same direction, newest first
- 2026PathReasoner-R1: Instilling Structured Reasoning into Pathology Vision-Language Model via Knowledge-Guided Policy Optimization29 Jan
- 2025PathVLM-R1: A Reinforcement Learning-Driven Reasoning Model for Pathology Visual-Language Tasks12 Apr
- 2025How Good is my Histopathology Vision-Language Foundation Model? A Holistic Benchmark17 Mar
- 2024CPath-Omni: A Unified Multimodal Foundation Model for Patch and Whole Slide Image Analysis in Computational Pathology16 Dec
- 2024OmniMedVQA: A New Large-Scale Comprehensive Evaluation Benchmark for Medical LVLM14 Feb
- 2024PathMMU: A Massive Multimodal Expert-Level Benchmark for Understanding and Reasoning in Pathology29 Jan
- 2023PathAsst: A Generative Foundation AI Assistant Towards Artificial General Intelligence of Pathology24 May
Other references · 12
- 2023Improved Baselines with Visual Instruction Tuningcited by 4,362
- 2024Qwen2-VL: Enhancing Vision-Language Model's Perception of the World at Any Resolutioncited by 4,151
- 2026GLM-5: from Vibe Coding to Agentic Engineeringcited by 502
- 2020PathVQA: 30000+ Questions for Medical Visual Question Answeringcited by 467
- 2025MedXpertQA: Benchmarking Expert-Level Medical Reasoning and Understandingcited by 212
- 2023Quilt-1M: One Million Image-Text Pairs for Histopathologycited by 192
- 2023Quilt-LLaVA: Visual Instruction Tuning by Extracting Localized Narratives from Open-Source Histopathology Videoscited by 84
- 2025PathFinder: A Multi-Modal Multi-Agent System for Medical Diagnostic Decision-Making Applied to Histopathologycited by 36
- 2025CPathAgent: An Agent-based Foundation Model for Interpretable High-Resolution Pathology Image Analysis Mimicking Pathologists' Diagnostic Logiccited by 27
- 2025HiDe: Rethinking The Zoom-IN method in High Resolution MLLMs via Hierarchical Decouplingcited by 16
- 2026Beyond Accuracy: Evaluating Visual Grounding In Multimodal Medical Reasoningcited by 6
- 2025PathVG: A New Benchmark and Dataset for Pathology Visual Groundingcited by 2
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Citing papers per year: 2026: 2.
2 papers.
Similar, not cited
Close in wording, no citation either way
- 2025Democratising Pathology Co-Pilots: An Open Pipeline and Dataset for Whole-Slide Vision-Language Modelling
- 2026Contamination, Prior, or Evidence? Decomposing and Training Evidence Use in Whole-Slide Vision-Language Models
- 2026PathView-Bench: Can Multimodal Large Language Models Achieve Fine-grained Multiscale Understanding of Pathology Images?
- 2026Enhancing Pathological VLMs with Cross-scale Reasoning
- 2026PathGLS: Evaluating Pathology Vision-Language Models without Ground Truth through Multi-Dimensional Consistency
- 2025Are Vision Language Models Ready for Clinical Diagnosis? A 3D Medical Benchmark for Tumor-centric Visual Question Answering
- 2024Prompting Medical Large Vision-Language Models to Diagnose Pathologies by Visual Question Answering
- 2026Benchmarking Vision-Language Models for Automated Pathology Diagnosis and Report Generation