Who Gets Missed in the Tail? Thresholded Subgroup Underdiagnosis in Long-Tailed Chest X-ray Classification
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Abstract (arXiv)
In chest X-ray (CXR) classification, acceptable ranking performance can still leave rare-positive patients below threshold, especially within subgroups. We study this pre-deployment fairness problem as an audit question: after a long-tailed multi-label CXR model is converted from scores into decisions, who is missed? Across VinDr-CXR and MIMIC-CXR/CXR-LT, we use a diagnostic ladder to separate class-level long-tail losses, subgroup-aware weighting, group robustness, and threshold selection. On VinDr-CXR, group-tail weighting followed by tail-aware thresholding reduces tail FNR from 0.665 to 0.269, sex worst-group FNR from 0.705 to 0.157, and age worst-group FNR from 0.822 to 0.133, while macro-mAP increases from 0.611 to 0.635. On MIMIC-CXR/CXR-LT, the same score-to-threshold comparison reduces tail FNR from 0.866 to 0.741 and lowers worst-group FNR across sex, age, race, and insurance; residual missed-positive rates nevertheless remain high. Paired bootstrap contrasts on VinDr support the thresholded FNR reductions, and GroupDRO reference runs indicate that aggregate group robustness alone does not remove rare subgroup misses in this setting. The study supports a narrow audit claim: rare-label fairness in CXR depends jointly on the finding, subgroup, and operating threshold, not on label frequency or ranking metrics alone.
Key facts. No citing papers in the map yet (data through 14 Oct 2026). Builds on 8 of its 14 references that are in the map. First posted on arXiv 4 Jul 2026.
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References · 8
- 2016Equality of Opportunity in Supervised Learningcited by 2,007
- 2019Distributionally Robust Neural Networks for Group Shifts: On the Importance of Regularization for Worst-Case Generalizationcited by 1,247
- 2019Class-Balanced Loss Based on Effective Number of Samplescited by 1,245
- 2020Asymmetric Loss For Multi-Label Classificationcited by 381
- 2020VinDr-CXR: An open dataset of chest X-rays with radiologist's annotationscited by 239
- 2024A Textbook Remedy for Domain Shifts: Knowledge Priors for Medical Image Analysiscited by 14
- 2025CXR-LT 2024: A MICCAI challenge on long-tailed, multi-label, and zero-shot disease classification from chest X-raycited by 10
- 2026CXR-LT 2026 Challenge: Multi-Center Long-Tailed and Zero Shot Chest X-ray Classificationcited by 1
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