FedProIn: Mitigating Client Drift for Learnable Prototypes in Federated Medical Imaging

Federated learning (FL) is severely hindered by statistical heterogeneity due to variations in scanners, acquisition protocols, and patient populations. Such non-IID data induces client drift during local optimization, leading to unstable convergence and suboptimal global models when parameter-based aggregation is applied. We propose a prototype-based, influence-aware federated learning framework (FedProIn) that uses multiple learnable class prototypes to capture shared semantic structures across heterogeneous clients. We introduce feature divergence loss and prototype contrastive loss to mitigate client drift by decomposing it into feature drift and prototype drift. In addition, we propose a normalized influence aggregation strategy that adaptively weights client prototypes according to their contribution to the global representation, reducing the impact of biased or low-quality updates. Experimental results on two publicly available medical datasets, HAM10000 and Matek-19, demonstrate that FedProIn achieves accuracies of (83.5% IID, 81.1% non-IID) on HAM10000 and (96.2% IID, 95.8% non-IID) on Matek-19, respectively, outperforming existing baselines in both conditions. Our code is available at https://github.com/harsh-kmr/FedProIn.