BioDivergence: A Benchmark and Evaluation Framework for Hidden Contextual Contradictions in Biomedical Abstracts
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Abstract (arXiv)
Biomedical findings often seem to conflict across studies, but many of these differences are context-dependent rather than true contradictions. Variations in cohort, geography, assay protocol, disease subtype, and clinical setting can make both claims locally valid. Existing NLI and scientific claim-verification benchmarks reduce such cases to entailment, contradiction, or neutral, failing to capture the contextual structure behind divergence. To address this, we introduce BioDivergence, an evaluation framework with a six-class conflict taxonomy, a 13-axis divergence ontology, and four structured outputs per claim pair: conflict type, divergence axes, dominant confounder, and reconciliation explanation. We release BioDivergence-Silver-v1.0, an article-disjoint silver benchmark of 11,865 claim pairs across five biomedical domains, alongside a legacy deduplicated variant for comparison. Results show notable ranking differences between the two variants, with the fine-tuned reference model dropping about 12 points under the article-disjoint setting, while Mistral-7B-Instruct-v0.3 achieves 0.5523 accuracy and 0.3894 contextual-F1 on the 842-example primary test set. BioDivergence offers a more faithful way to distinguish contextual divergence from direct contradiction and to separate article-level memorization from genuine task learning.
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References · 13
- 2018FEVER: a large-scale dataset for Fact Extraction and VERificationcited by 1,362
- 2020Fact or Fiction: Verifying Scientific Claimscited by 546
- 2021Get Your Vitamin C! Robust Fact Verification with Contrastive Evidencecited by 222
- 2024MediQ: Question-Asking LLMs and a Benchmark for Reliable Interactive Clinical Reasoningcited by 145
- 2024ClashEval: Quantifying the tug-of-war between an LLM's internal prior and external evidencecited by 109
- 2025Measuring what Matters: Construct Validity in Large Language Model Benchmarkscited by 102
- 2022SciFact-Open: Towards open-domain scientific claim verificationcited by 94
- 2024RAGChecker: A Fine-grained Framework for Diagnosing Retrieval-Augmented Generationcited by 59
- 2024WikiContradict: A Benchmark for Evaluating LLMs on Real-World Knowledge Conflicts from Wikipediacited by 43
- 2020Evidence Inference 2.0: More Data, Better Modelscited by 39
- 2024DiReCT: Diagnostic Reasoning for Clinical Notes via Large Language Modelscited by 14
- 2024Do Automatic Factuality Metrics Measure Factuality? A Critical Evaluationcited by 9
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