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Distributional Causal Mediation via Conditional Generative Modeling

arXiv 2605.01765 ↗First posted 3 May 2026stat.ML cs.LGcited by 0

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Abstract (arXiv)

Mediation analysis has traditionally focused on outcome-level summary contrasts, such as mean effects, which may obscure substantial distributional changes induced by complex and nonlinear causal mechanisms. We propose Distributional Causal Mediation Analysis (DCMA), a generative learning framework for identifying and estimating treatment effects on entire outcome distributions transmitted through multiple mediators. DCMA learns conditional generative models for the mediators and the outcome, recovering the relevant conditional distributions from observational data. Leveraging the identification formulas, it reconstructs interventional outcome distributions via Monte Carlo forward simulation by noise resampling, enabling the capture of both classical summary effects and rich distributional contrasts such as energy distance and the Wasserstein distance. Analytical error bounds are derived to decompose how estimation errors in the learned conditional models propagate to the reconstructed interventional outcome distributions. The empirical effectiveness of DCMA is demonstrated through numerical experiments and real-world data applications.

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References · 14

  1. 2017Improved Training of Wasserstein GANscited by 2,223
  2. 2017Causal Effect Inference with Deep Latent-Variable Modelscited by 408
  3. 2023Engression: Extrapolation through the Lens of Distributional Regressioncited by 49
  4. 2021Semiparametric counterfactual density estimationcited by 42
  5. 2021Conditional Distributional Treatment Effect with Kernel Conditional Mean Embeddings and U-Statistic Regressioncited by 40
  6. 2022Robust and Agnostic Learning of Conditional Distributional Treatment Effectscited by 18
  7. 2018Causal effects based on distributional distancescited by 15
  8. 2023Wasserstein Generative Regressioncited by 12
  9. 2025On Efficient Estimation of Distributional Treatment Effects under Covariate-Adaptive Randomizationcited by 6
  10. 2019Clarifying causal mediation analysis for the applied researcher: Defining effects based on what we want to learncited by 5
  11. 2021Sequential Kernel Embedding for Mediated and Time-Varying Dose Response Curvescited by 5
  12. 2020Nonparametric inference for interventional effects with multiple mediatorscited by 3
2 more
  1. 2020Non-linear Mediation Analysis with High-dimensional Mediators whose Causal Structure is Unknowncited by 1
  2. 2025Causal Mediation Analysis with Multiple Mediators: A Simulation Approachcited by 1

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