Instance Awareness of Multi-class Semantic Segmentation Loss Functions

Instance-sensitive losses for semantic segmentation such as blob loss and CC loss were designed to address instance imbalance, ensuring small lesions generate the same gradient as large ones, but operate only on single-class segmentation. In multi-class settings, class imbalance poses an additional problem: rare classes with few instances receive a disproportionately small share of the training signal. We show that extending instance-sensitive losses to multi-class segmentation via a one-vs-rest class decomposition repurposes them to also address class imbalance, as uniform averaging over classes ensures each class contributes equally regardless of frequency. We further show that inverse-size weighting, which destabilizes training when applied globally due to weight imbalances across rare and common classes, becomes effective when integrated within the per-component loss, confining the reweighting to each component's spatial context. On the BraTS-METS 2025 dataset (260 test cases), multi-class CC loss improves foreground Dice (0.64 +/- 0.26 vs. 0.59 +/- 0.27 baseline) and rare-class Dice, while maintaining Panoptic Quality at DSC threshold 0.5. Multi-class blob loss achieves the best Panoptic Quality at threshold 0.5 (0.40 +/- 0.24 vs. 0.38 +/- 0.25 baseline) and recognition quality (0.53 +/- 0.29 vs. 0.49 +/- 0.30). Integrating inverse-size weighting within the per-component loss increases rare-class Dice to 0.44 +/- 0.36 at the cost of reduced detection quality.