AC-MIL: Weakly Supervised Atrial LGE-MRI Quality Assessment via Adversarial Concept Disentanglement
Not on the map. Why?
Abstract (arXiv)
High-quality Late Gadolinium Enhancement (LGE) MRI can be helpful for atrial fibrillation management, yet scan quality is frequently compromised by patient motion, irregular breathing, and suboptimal image acquisition timing. While Multiple Instance Learning (MIL) has emerged as a powerful tool for automated quality assessment under weak supervision, current state-of-the-art methods map localized visual evidence to a single, opaque global feature vector. This black box approach fails to provide actionable feedback on specific failure modes, obscuring whether a scan degrades due to motion blur, inadequate contrast, or a lack of anatomical context. In this paper, we propose Adversarial Concept-MIL (AC-MIL), a weakly supervised framework that decomposes global image quality into clinically defined radiological concepts using only volume-level supervision. To capture latent quality variations without entangling predefined concepts, our framework incorporates an unsupervised residual branch guided by an adversarial erasure mechanism to strictly prevent information leakage. Furthermore, we introduce a spatial diversity constraint that penalizes overlap between distinct concept attention maps, ensuring localized and interpretable feature extraction. Extensive experiments on a clinical dataset of atrial LGE-MRI volumes demonstrate that AC-MIL successfully opens the MIL black box, providing highly localized spatial concept maps that allow clinicians to pinpoint the specific causes of non-diagnostic scans. Crucially, our framework achieves this deep clinical transparency while maintaining highly competitive ordinal grading performance against existing baselines. Code to be released on acceptance.
Key facts. No citing papers in the map yet (data through 14 Oct 2026). Builds on 8 of its 21 references that are in the map. First posted on arXiv 11 Apr 2026.
Builds on
8 of 21 references.
References · 8
- 2016Towards Evaluating the Robustness of Neural Networkscited by 2,998
- 2014Unsupervised Domain Adaptation by Backpropagationcited by 1,917
- 2020Concept Bottleneck Modelscited by 1,032
- 2020Dual-stream Multiple Instance Learning Network for Whole Slide Image Classification with Self-supervised Contrastive Learningcited by 478
- 2022DTFD-MIL: Double-Tier Feature Distillation Multiple Instance Learning for Histopathology Whole Slide Image Classificationcited by 256
- 2021Deep Neural Networks for Rank-Consistent Ordinal Regression Based On Conditional Probabilitiescited by 59
- 2024HAMIL-QA: Hierarchical Approach to Multiple Instance Learning for Atrial LGE MRI Quality Assessmentcited by 2
- 2025In-hoc Concept Representations to Regularise Deep Learning in Medical Imagingcited by 2
Built on by
Not cited yet.