Is Clinical Text Enough? A Multimodal Study on Mortality Prediction in Heart Failure Patients
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Abstract (arXiv)
Accurate short-term mortality prediction in heart failure (HF) remains challenging, particularly when relying on structured electronic health record (EHR) data alone. We evaluate transformer-based models on a French HF cohort, comparing text-only, structured-only, multimodal, and LLM-based approaches. Our results show that enriching clinical text with entity-level representations improves prediction over CLS embeddings alone, and that supervised multimodal fusion of text and structured variables achieves the best overall performance. In contrast, large language models perform inconsistently across modalities and decoding strategies, with text-only prompts outperforming structured or multimodal inputs. These findings highlight that entity-aware multimodal transformers offer the most reliable solution for short-term HF outcome prediction, while current LLM prompting remains limited for clinical decision support.
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References · 10
- 2019ClinicalBERT: Modeling Clinical Notes and Predicting Hospital Readmissioncited by 487
- 2020Med-BERT: pre-trained contextualized embeddings on large-scale structured electronic health records for disease predictioncited by 368
- 2024A Thorough Examination of Decoding Methods in the Era of LLMscited by 112
- 2023Diagnostic Reasoning Prompts Reveal the Potential for Large Language Model Interpretability in Medicinecited by 83
- 2022A Multimodal Transformer: Fusing Clinical Notes with Structured EHR Data for Interpretable In-Hospital Mortality Predictioncited by 48
- 2025Quantifying the Reasoning Abilities of LLMs on Real-world Clinical Casescited by 28
- 2024Multimodal Fusion of EHR in Structures and Semantics: Integrating Clinical Records and Notes with Hypergraph and LLMcited by 10
- 2019Towards unstructured mortality prediction with free-text clinical notescited by 8
- 2023Unlocking Anticipatory Text Generation: A Constrained Approach for Large Language Models Decodingcited by 4
- 2022Assessing mortality prediction through different representation models based on concepts extracted from clinical notescited by 1
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