mlsanityData to 7 Oct 2026

Robust White Blood Cell Classification with Stain-Normalized Decoupled Learning and Ensembling

arXiv 2603.01976 ↗First posted 2 Mar 2026cs.CVcited by 1

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Abstract (arXiv)

White blood cell (WBC) classification is fundamental for hematology applications such as infection assessment, leukemia screening, and treatment monitoring. However, real-world WBC datasets present substantial appearance variations caused by staining and scanning conditions, as well as severe class imbalance in which common cell types dominate while rare but clinically important categories are underrepresented. To address these challenges, we propose a stain-normalized, decoupled training framework that first learns transferable representations using instance-balanced sampling, and then rebalances the classifier with class-aware sampling and a hybrid loss combining effective-number weighting and focal modulation. In inference stage, we further enhance robustness by ensembling various trained backbones with test-time augmentation. Our approach achieved the top rank on the leaderboard of the WBCBench 2026: Robust White Blood Cell Classification Challenge at ISBI 2026.

Key facts. Cited by 1 paper in the map (data through 7 Oct 2026). Builds on 5 of its 15 references that are in the map. First posted on arXiv 2 Mar 2026.

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5 of 15 references.

References · 5

  1. 2019RandAugment: Practical automated data augmentation with a reduced search spacecited by 2,261
  2. 2019Class-Balanced Loss Based on Effective Number of Samplescited by 1,239
  3. 2019Decoupling Representation and Classifier for Long-Tailed Recognitioncited by 806
  4. 2026Handling Supervision Scarcity in Chest X-ray Classification: Long-Tailed and Zero-Shot Learningcited by 4
  5. 2026Domain-invariant Mixed-domain Semi-supervised Medical Image Segmentation with Clustered Maximum Mean Discrepancy Alignmentcited by 1

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