Fixed-Budget Parameter-Efficient Training with Frozen Encoders Improves Multimodal Chest X-Ray Classification
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Abstract (arXiv)
Multimodal chest X-Ray analysis often fine-tunes large vision-language models, which is computationally costly. We study parameter-efficient training (PET) strategies, including frozen encoders, BitFit, LoRA, and adapters for multi-label classification on the Indiana University Chest X-Ray dataset (3,851 image-report pairs; 579 test samples). To mitigate data leakage, we redact pathology terms from reports used as text inputs while retaining clinical context. Under a fixed parameter budget (2.37M parameters, 2.51% of total), all PET variants achieve AUROC between 0.892 and 0.908, outperforming full fine-tuning (0.770 AUROC), which uses 94.3M trainable parameters, a 40x reduction. External validation on CheXpert (224,316 images, 58x larger) confirms scalability: all PET methods achieve >0.69 AUROC with <9% trainable parameters, with Adapter achieving best performance (0.7214 AUROC). Budget-matched comparisons reveal that vision-only models (0.653 AUROC, 1.06M parameters) outperform budget-matched multimodal models (0.641 AUROC, 1.06M parameters), indicating improvements arise primarily from parameter allocation rather than cross-modal synergy. While PET methods show degraded calibration (ECE: 0.29-0.34) compared to simpler models (ECE: 0.049), this represents a tractable limitation addressable through post-hoc calibration methods. These findings demonstrate that frozen encoder strategies provide superior discrimination at substantially reduced computational cost, though calibration correction is essential for clinical deployment.
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References · 16
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- 2019CheXpert: A Large Chest Radiograph Dataset with Uncertainty Labels and Expert Comparisoncited by 1,423
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- 2021BitFit: Simple Parameter-efficient Fine-tuning for Transformer-based Masked Language-modelscited by 1,245
- 2019ClinicalBERT: Modeling Clinical Notes and Predicting Hospital Readmissioncited by 493
- 2017CheXNet: Radiologist-Level Pneumonia Detection on Chest X-Rays with Deep Learningcited by 461
- 2024Comparative Analysis of Resource-Efficient CNN Architectures for Brain Tumor Classificationcited by 3
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- 2023ELIXR: Towards a general purpose X-ray artificial intelligence system through alignment of large language models and radiology vision encoders
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- 2026A data- and compute-efficient chest X-ray foundation model beyond aggressive scaling
- 2023UniChest: Conquer-and-Divide Pre-training for Multi-Source Chest X-Ray Classification
- 2025CheXPO: Preference Optimization for Chest X-ray VLMs with Counterfactual Rationale
- 2024RE-tune: Incremental Fine Tuning of Biomedical Vision-Language Models for Multi-label Chest X-ray Classification