mlsanityData to 7 Oct 2026

Neural Diffusion Processes for Physically Interpretable Survival Prediction

arXiv 2510.00733 ↗First posted 1 Oct 2025cs.LG cs.AI q-bio.QMcited by 0

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Abstract (arXiv)

We introduce DeepFHT, a survival-analysis framework that couples deep neural networks with first hitting time (FHT) distributions from stochastic process theory. Time to event is represented as the first passage of a latent diffusion process to an absorbing boundary. A neural network maps input variables to physically meaningful parameters including initial condition, drift, and diffusion, within a chosen FHT process such as Brownian motion, both with drift and driftless. This yields closed- form survival and hazard functions and captures time-varying risk without assuming proportional- hazards. We compare DeepFHT with Cox regression using synthetic and real-world datasets. The method achieves predictive accuracy on par with the state-of-the-art approach, while maintaining a physics- based interpretable parameterization that elucidates the relation between input features and risk. This combination of stochastic process theory and deep learning provides a principled avenue for modeling survival phenomena in complex systems

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References · 3

  1. 2019Optuna: A Next-generation Hyperparameter Optimization Frameworkcited by 2,455
  2. 2022SurvSet: An open-source time-to-event dataset repositorycited by 15
  3. 2025Beyond Cox Models: Assessing the Performance of Machine-Learning Methods in Non-Proportional Hazards and Non-Linear Survival Analysiscited by 3

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  1. 2024An Introduction to Deep Survival Analysis Models for Predicting Time-to-Event Outcomes
  2. 2025SurvDiff: A Diffusion Model for Generating Synthetic Data in Survival Analysis
  3. 2024Neural Flow Diffusion Models: Learnable Forward Process for Improved Diffusion Modelling
  4. 2021WaveNet-Based Deep Neural Networks for the Characterization of Anomalous Diffusion (WADNet)
  5. 2026Physics-informed Diffusion Generative Model for Time-Series Data Synthesis in Dynamic Systems
  6. 2026SDPM: Survival Diffusion Probabilistic Model for Continuous-Time Survival Analysis
  7. 2026PHDME: Physics-Informed Diffusion Models without Explicit Governing Equations
  8. 2023Closing the ODE-SDE gap in score-based diffusion models through the Fokker-Planck equation