nnFilterMatch: A Unified Semi-Supervised Learning Framework with Uncertainty-Aware Pseudo-Label Filtering for Efficient Medical Segmentation

Semi-supervised learning (SSL) has emerged as a promising paradigm in medical image segmentation, offering competitive performance while substantially reducing the need for extensive manual annotation. When combined with active learning (AL), these strategies further minimize annotation burden by selectively incorporating the most informative samples. However, conventional SSLAL hybrid approaches often rely on iterative and loop-based retraining cycles after each annotation round, incurring significant computational overhead and limiting scalability in clinical applications. In this study, we present a novel, annotation-efficient, and self-adaptive deep segmentation framework that integrates SSL with entropy-based pseudo-label filtering (FilterMatch), an AL-inspired mechanism, within the single-pass nnU-Net training segmentation framework (nnFilterMatch). By selectively excluding high-confidence pseudo-labels during training, our method circumvents the need for retraining loops while preserving the benefits of uncertainty-guided learning. We validate the proposed framework across multiple clinical segmentation benchmarks and demonstrate that it achieves performance comparable to or exceeding fully supervised models, even with only 5%--20% labeled data. This work introduces a scalable, end-to-end learning strategy for reducing annotation demands in medical image segmentation without compromising accuracy. Code is available here: https://github.com/Ordi117/nnFilterMatch.git.