Quantization-Aware Neuromorphic Architecture for Skin Lesion Classification on Resource-Constrained Devices

On-device skin lesion analysis is constrained by the compute and energy cost of conventional CNN inference and by the need for lightweight calibration under clinical data shift. Neuromorphic processors provide event-driven sparse computation, but practical deployment is often limited by CNN-to-SNN conversion failures, including unsupported operators, quantization distortion, and accuracy degradation under class imbalance. We propose QANA, a quantization-aware CNN backbone within an end-to-end pipeline for conversion-stable neuromorphic execution. QANA improves conversion robustness by bounding intermediate activations, aligning normalization with low-bit quantization, and replacing conversion-fragile components with spike-compatible transformations. Efficient representation is achieved through Ghost-based feature generation, spatially-aware efficient channel attention, and squeeze-and-excitation modules whose operations can be quantized, folded, or lowered into integer graph operations. The quantized projection head produces SNN-ready logits and supports lightweight readout calibration without full retraining or data offloading. On HAM10000, QANA achieves 91.6% Top-1 accuracy and 91.0% macro F1, improving the strongest converted SNN baseline by 3.5 points in accuracy and 12.1 points in macro F1. On a clinical dataset, QANA achieves 90.8% Top-1 accuracy and 81.7% macro F1, improving the strongest baseline by 3.2 points in accuracy and 3.6 points in macro F1. On BrainChip Akida, QANA runs in 1.5 ms with 1.7 mJ per image, outperforming the strongest size-matched Akida baseline by 4.1 points in accuracy, 10.0 points in macro F1, 21.1% in latency, and 22.7% in energy.