mlsanityData to 14 Oct 2026

Do "New Snow Tablets" Contain Snow? Large Language Models Over-Rely on Names to Identify Ingredients of Chinese Drugs

arXiv 2504.03786 ↗First posted 3 Apr 2025cs.CLcited by 1

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Abstract (arXiv)

Traditional Chinese Medicine (TCM) has seen increasing adoption in healthcare, with specialized Large Language Models (LLMs) emerging to support clinical applications. A fundamental requirement for these models is accurate identification of TCM drug ingredients. In this paper, we evaluate how general and TCM-specialized LLMs perform when identifying ingredients of Chinese drugs. Our systematic analysis reveals consistent failure patterns: models often interpret drug names literally, overuse common herbs regardless of relevance, and exhibit erratic behaviors when faced with unfamiliar formulations. LLMs also fail to understand the verification task. These findings demonstrate that current LLMs rely primarily on drug names rather than possessing systematic pharmacological knowledge. To address these limitations, we propose a Retrieval Augmented Generation (RAG) approach focused on ingredient names. Experiments across 220 TCM formulations show our method significantly improves accuracy from approximately 50% to 82% in ingredient verification tasks. Our work highlights critical weaknesses in current TCM-specific LLMs and offers a practical solution for enhancing their clinical reliability.

Key facts. Cited by 1 paper in the map (data through 14 Oct 2026). Builds on 9 of its 12 references that are in the map. First posted on arXiv 3 Apr 2025.

Builds on

9 of 12 references.

References · 9

  1. 2024A Careful Examination of Large Language Model Performance on Grade School Arithmeticcited by 191
  2. 2023DoctorGLM: Fine-tuning your Chinese Doctor is not a Herculean Taskcited by 131
  3. 2023CMB: A Comprehensive Medical Benchmark in Chinesecited by 115
  4. 2023ChiMed-GPT: A Chinese Medical Large Language Model with Full Training Regime and Better Alignment to Human Preferencescited by 43
  5. 2023Taiyi: A Bilingual Fine-Tuned Large Language Model for Diverse Biomedical Taskscited by 36
  6. 2024MedFuzz: Exploring the Robustness of Large Language Models in Medical Question Answeringcited by 26
  7. 2024Language Models are Surprisingly Fragile to Drug Names in Biomedical Benchmarkscited by 17
  8. 2024BianCang: A Traditional Chinese Medicine Large Language Modelcited by 12
  9. 2024Difficult Task Yes but Simple Task No: Unveiling the Laziness in Multimodal LLMscited by 3

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Cited by year (2026 to 14 Oct)

Citing papers per year: 2026: 1.

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  1. 2025ZhiFangDanTai: Fine-tuning Graph-based Retrieval-Augmented Generation Model for Traditional Chinese Medicine Formula
  2. 2025MTCMB: A Multi-Task Benchmark Framework for Evaluating LLMs on Knowledge, Reasoning, and Safety in Traditional Chinese Medicine
  3. 2025TCM-Ladder: A Benchmark for Multimodal Question Answering on Traditional Chinese Medicine
  4. 2025TCM-Eval: An Expert-Level Dynamic and Extensible Benchmark for Traditional Chinese Medicine
  5. 2025OpenTCM: A GraphRAG-Empowered LLM-based System for Traditional Chinese Medicine Knowledge Retrieval and Diagnosis
  6. 2026TCMClinicalReason-Bench: Can Language Models Reason from Pathogenesis to Prescription over Real-World Clinical Cases?
  7. 2026DeepTCM1.0: A Multi-Expert AI Agent for Deciphering Mechanisms of Chinese Herbal Formulae Based on General Large Language Models
  8. 2025ShizhenGPT: Towards Multimodal LLMs for Traditional Chinese Medicine