Modality-Agnostic Brain Lesion Segmentation with Privacy-aware Continual Learning

Traditional brain lesion segmentation models for multi-modal MRI are typically tailored to specific pathologies, relying on datasets with predefined modalities. Adapting to new MRI modalities or pathologies often requires training separate models, which contrasts with how medical professionals incrementally expand their expertise by learning from diverse datasets over time. Inspired by this human learning process, we propose a unified segmentation model capable of sequentially learning from multiple datasets with varying modalities and pathologies. Our approach leverages a privacy-aware continual learning framework that integrates a mixture-of-experts mechanism and dual knowledge distillation to mitigate catastrophic forgetting while not compromising performance on newly encountered datasets. Extensive experiments across five diverse brain MRI datasets and four dataset sequences demonstrate the effectiveness of our framework in maintaining a single adaptable model, capable of handling varying hospital protocols, imaging modalities, and disease types. Compared to widely used privacy-aware continual learning methods such as LwF, SI, EWC, MiB, and TED, our method achieves an average Dice score improvement of approximately 14%. Our framework represents a significant step toward more versatile and practical brain lesion segmentation models, with implementation available on hrefhttps://github.com/xmindflow/BrainCLGitHub.