MedPlan: A Two-Stage RAG-Based System for Personalized Medical Plan Generation
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Abstract (arXiv)
Despite recent success in applying large language models (LLMs) to electronic health records (EHR), most systems focus primarily on assessment rather than treatment planning. We identify three critical limitations in current approaches: they generate treatment plans in a single pass rather than following the sequential reasoning process used by clinicians; they rarely incorporate patient-specific historical context; and they fail to effectively distinguish between subjective and objective clinical information. Motivated by the SOAP methodology (Subjective, Objective, Assessment, Plan), we introduce ours, a novel framework that structures LLM reasoning to align with real-life clinician workflows. Our approach employs a two-stage architecture that first generates a clinical assessment based on patient symptoms and objective data, then formulates a structured treatment plan informed by this assessment and enriched with patient-specific information through retrieval-augmented generation. Comprehensive evaluation demonstrates that our method significantly outperforms baseline approaches in both assessment accuracy and treatment plan quality.
Key facts. Cited by 5 papers in the map (data through 14 Oct 2026). Builds on 12 of its 40 references that are in the map. First posted on arXiv 23 Mar 2025.
Builds on
12 of 40 references.
References · 12
- 2020Retrieval-Augmented Generation for Knowledge-Intensive NLP Taskscited by 9,297
- 2019BERTScore: Evaluating Text Generation with BERTcited by 5,512
- 2020Dense Passage Retrieval for Open-Domain Question Answeringcited by 3,824
- 2019Passage Re-ranking with BERTcited by 645
- 2022An Analysis of Fusion Functions for Hybrid Retrievalcited by 51
- 2025MedicalAgentsBench for Complex Medical Reasoning: Comparing Internalized Reasoning Models versus Externalized Agent-based Frameworkscited by 40
- 2025Quantifying the Reasoning Abilities of LLMs on Real-world Clinical Casescited by 29
- 2024Towards Resilient and Efficient LLMs: A Comparative Study of Efficiency, Performance, and Adversarial Robustnesscited by 22
- 2024Automated radiotherapy treatment planning guided by GPT-4Visioncited by 12
- 2025Towards Conversational AI for Disease Managementcited by 11
- 2024Multi-OphthaLingua: A Multilingual Benchmark for Assessing and Debiasing LLM Ophthalmological QA in LMICscited by 10
- 2025MAP: Evaluation and Multi-Agent Enhancement of Large Language Models for Inpatient Pathwayscited by 10
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Citing papers per year: 2025: 1; 2026: 4.
5 papers.
- 2026Toward Personalized LLM-Powered Agents: Foundations, Evaluation, and Future Directionscited by 14
- 2025BudgetLeak: Membership Inference Attacks on RAG Systems via the Generation Budget Side Channelcited by 3
- 2026EHRNavigator: A Multi-Agent System for Patient-Level Clinical Question Answering over Heterogeneous Electronic Health Recordscited by 1
- 2026CAREAgent: Clinical Agent with Structured Reasoning and Tool-Integrated for Order Generationcited by 0
- 2026ARMED: Adaptive Retrieval-Augmented Medication Recommendationcited by 0
- 2026ARMED: Adaptive Retrieval-Augmented Medication Recommendation12 Oct 2026
- 2026CAREAgent: Clinical Agent with Structured Reasoning and Tool-Integrated for Order Generation31 May 2026
- 2026Toward Personalized LLM-Powered Agents: Foundations, Evaluation, and Future Directions26 Feb 2026
- 2026EHRNavigator: A Multi-Agent System for Patient-Level Clinical Question Answering over Heterogeneous Electronic Health Records15 Jan 2026
- 2025BudgetLeak: Membership Inference Attacks on RAG Systems via the Generation Budget Side Channel15 Nov 2025
Similar, not cited
Close in wording, no citation either way
- 2025Retrieval-Augmented Framework for LLM-Based Clinical Decision Support
- 2025Evaluating Retrieval-Augmented Generation vs. Long-Context Input for Clinical Reasoning over EHRs
- 2025Retrieval-Augmented Generation in Medicine: A Scoping Review of Technical Implementations, Clinical Applications, and Ethical Considerations
- 2025CARE-RAG - Clinical Assessment and Reasoning in RAG
- 2025Reviewing Clinical Knowledge in Medical Large Language Models: Training and Beyond
- 2026When Reasoning Hurts: Source-Aware Evaluation of Frontier LLMs for Clinical SOAP Note Generation
- 2025Medical Reasoning in the Era of LLMs: A Systematic Review of Enhancement Techniques and Applications
- 2025MedCoT-RAG: Causal Chain-of-Thought RAG for Medical Question Answering