Asynchronous Federated Continual Segmentation with Evolving Clients and Label Spaces

Federated learning seeks to foster collaboration among distributed clients while preserving the privacy of their local data. Traditional federated learning methods typically assume a fixed setting, where participating clients, client data, and learning objectives remain unchanged. However, in real-world scenarios, a federation may evolve over time, with changes in both its client composition and target label space. In this evolving federated setting, conventional round-wise model aggregation becomes inflexible, as each federation update requires repeated communication, repeated local computation, and synchronized participation from all accumulated clients. To address this limitation, we propose CA-MMDS, a continual multiple-model distillation framework for federated continual segmentation with asynchronous clients and evolving label spaces. Instead of repeatedly aggregating model parameters from all clients, CA-MMDS maintains a server-side archive of client models and updates the global model through proxy-based distillation from multiple archived local models. When new clients join or existing clients evolve, only the newly added or updated local models need to be uploaded, while unchanged clients can remain offline and continue to contribute through their archived models. This design substantially reduces communication and computation costs while enabling flexible asynchronous cooperation among evolving clients. Using multi-class 3D abdominal CT segmentation as an application task, we demonstrate that CA-MMDS efficiently incorporates evolving client knowledge while achieving competitive segmentation performance.