BioMamba: Leveraging Spectro-Temporal Embedding in Bidirectional Mamba for Enhanced Biosignal Classification
On the map: State-space sequence models (S4, Mamba) → Physiological signal modeling
Abstract (arXiv)
Biological signals, such as electroencephalograms (EEGs) and electrocardiograms (ECGs), play a pivotal role in numerous clinical practices, such as diagnosing brain and cardiac arrhythmic diseases. Existing methods for biosignal classification rely on Attention-based frameworks with dense Feed Forward layers, which lead to inefficient learning, high computational overhead, and suboptimal performance. In this work, we introduce BioMamba, a Spectro-Temporal Embedding strategy applied to the Bidirectional Mamba framework with Sparse Feed Forward layers to enable effective learning of biosignal sequences. By integrating these three key components, BioMamba effectively addresses the limitations of existing methods. Extensive experiments demonstrate that BioMamba significantly outperforms state-of-the-art methods with marked improvement in classification performance. The advantages of the proposed BioMamba include (1) Reliability: BioMamba consistently delivers robust results, confirmed across six evaluation metrics. (2) Efficiency: We assess both model and training efficiency, the BioMamba demonstrates computational effectiveness by reducing model size and resource consumption compared to existing approaches. (3) Generality: With the capacity to effectively classify a diverse set of tasks, BioMamba demonstrates adaptability and effectiveness across various domains and applications.
Key facts. Cited by 3 papers in the map (data through 14 Oct 2026). Placed in Physiological signal modeling, one of 10 directions in State-space sequence models (S4, Mamba). Builds on 28 of its 61 references that are in the map. First posted on arXiv 14 Mar 2025.
Builds on
28 of 61 references.
References · 28
- 2017Attention Is All You Needcited by 60,361
- 2020An Image is Worth 16x16 Words: Transformers for Image Recognition at Scalecited by 30,186
- 2019PyTorch: An Imperative Style, High-Performance Deep Learning Librarycited by 20,305
- 2023Mamba: Linear-Time Sequence Modeling with Selective State Spacescited by 4,718
- 2018UMAP: Uniform Manifold Approximation and Projection for Dimension Reductioncited by 2,898
- 2021Efficiently Modeling Long Sequences with Structured State Spacescited by 2,465
- 2022A Time Series is Worth 64 Words: Long-term Forecasting with Transformerscited by 2,039
- 2018An Empirical Evaluation of Generic Convolutional and Recurrent Networks for Sequence Modelingcited by 1,476
- 2020Transformer Feed-Forward Layers Are Key-Value Memoriescited by 1,336
- 2024Vision Mamba: Efficient Visual Representation Learning with Bidirectional State Space Modelcited by 1,056
- 2023iTransformer: Inverted Transformers Are Effective for Time Series Forecastingcited by 931
- 2022Simplified State Space Layers for Sequence Modelingcited by 788
16 more
- 2016EEGNet: A Compact Convolutional Network for EEG-based Brain-Computer Interfacescited by 628
- 2022Hungry Hungry Hippos: Towards Language Modeling with State Space Modelscited by 499
- 2022Non-stationary Transformers: Exploring the Stationarity in Time Series Forecastingcited by 391
- 2022Long Range Language Modeling via Gated State Spacescited by 265
- 2024Is Mamba Effective for Time Series Forecasting?cited by 114
- 2021Self-Supervised Graph Neural Networks for Improved Electroencephalographic Seizure Analysiscited by 76
- 2024Multi-Scale VMamba: Hierarchy in Hierarchy Visual State Space Modelcited by 62
- 2024MoE-Mamba: Efficient Selective State Space Models with Mixture of Expertscited by 60
- 2023On the Constrained Time-Series Generation Problemcited by 54
- 2024Medformer: A Multi-Granularity Patching Transformer for Medical Time-Series Classificationcited by 53
- 2024EEG2Rep: Enhancing Self-supervised EEG Representation Through Informative Masked Inputscited by 50
- 2022EEG based Emotion Recognition: A Tutorial and Reviewcited by 43
- 2024DenseMamba: State Space Models with Dense Hidden Connection for Efficient Large Language Modelscited by 22
- 2022Hierarchical Deep Learning with Generative Adversarial Network for Automatic Cardiac Diagnosis from ECG Signalscited by 15
- 2024REST: Efficient and Accelerated EEG Seizure Analysis through Residual State Updatescited by 12
- 2024TimeLDM: Latent Diffusion Model for Unconditional Time Series Generationcited by 10
Built on by
Citing papers per year: 2025: 1; 2026: 2.
3 papers.
- 2026LuMamba: Latent Unified Mamba for Electrode Topology-Invariant and Efficient EEG Modelingcited by 4
- 2025CoSupFormer : A Contrastive Supervised learning approach for EEG signal Classificationcited by 1
- 2026Emotion as a Distribution: Joint Valence-Arousal Probability Learning for Speaker-Independent Multimodal Emotion Recognitioncited by 0
- 2026Emotion as a Distribution: Joint Valence-Arousal Probability Learning for Speaker-Independent Multimodal Emotion Recognition4 Sep 2026
- 2026LuMamba: Latent Unified Mamba for Electrode Topology-Invariant and Efficient EEG Modeling19 Mar 2026
- 2025CoSupFormer : A Contrastive Supervised learning approach for EEG signal Classification24 Sep 2025
Similar, not cited
Close in wording, no citation either way
- 2026MedMamba: Recasting Mamba for Medical Time Series Classification
- 2026PanLUNA: An Efficient and Robust Query-Unified Multimodal Model for Edge Biosignal Intelligence
- 2025FEMBA: Efficient and Scalable EEG Analysis with a Bidirectional Mamba Foundation Model
- 2025Channel-Imposed Fusion: A Simple yet Effective Method for Medical Time Series Classification
- 2025SAMBA: Toward a Long-Context EEG Foundation Model via Spatial Embedding and Differential Mamba
- 2024BiT-MamSleep: Bidirectional Temporal Mamba for EEG Sleep Staging
- 2025ECG-Mamba-V2: Architectural Refinements to a Bidirectional State Space Model for Multi-Label 12-Lead ECG Classification
- 2026AF-Mamba: Efficient Long-Term Signal Modeling for Early Prediction of Atrial Fibrillation Onset