Learning 3D Medical Image Models From Brain Functional Connectivity Network Supervision For Mental Disorder Diagnosis

In MRI-based mental disorder diagnosis, most previous studies focus on functional connectivity network (FCN) derived from functional MRI (fMRI). However, the small size of annotated fMRI datasets restricts its wide application. Meanwhile, structural MRIs (sMRIs), such as 3D T1-weighted (T1w) MRI, which are commonly used and readily accessible in clinical settings, are often overlooked. To integrate the complementary information from both function and structure for improved diagnostic accuracy, we propose CINP (Contrastive Image-Network Pre-training), a framework that employs contrastive learning between sMRI and FCN. During pre-training, we incorporate masked image modeling and network-image matching to enhance visual representation learning and modality alignment. Since the CINP facilitates knowledge transfer from FCN to sMRI, we introduce network prompting. It utilizes only sMRI from suspected patients and a small amount of FCNs from different patient classes for diagnosing mental disorders, which is practical in real-world clinical scenario. The competitive performance on three mental disorder diagnosis tasks demonstrate the effectiveness of the CINP in integrating multimodal MRI information, as well as the potential of incorporating sMRI into clinical diagnosis using network prompting.