HexGen-2: Disaggregated Generative Inference of LLMs in Heterogeneous Environment
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Abstract (arXiv)
Disaggregating the prefill and decoding phases represents an effective new paradigm for generative inference of large language models (LLM), which eliminates prefill-decoding interference and optimizes resource allocation. However, it is still an open problem about how to deploy the disaggregated inference paradigm across a group of heterogeneous GPUs, which can be an economical alternative to deployment over homogeneous high-performance GPUs. Towards this end, we introduce HexGen-2, a distributed system for efficient and economical LLM serving on heterogeneous GPUs following the disaggregated paradigm. Built on top of HexGen, the core component of HexGen-2 is a scheduling algorithm that formalizes the allocation of disaggregated LLM inference computations and communications over heterogeneous GPUs and network connections as a constraint optimization problem. We leverage the graph partitioning and max-flow algorithms to co-optimize resource allocation, parallel strategies for distinct inference phases, and the efficiency of inter-phase key-value (KV) cache communications. We conduct extensive experiments to evaluate HexGen-2, i.e., on OPT (30B) and Llama-2 (70B) models in various real-world settings, the results reveal that HexGen-2 delivers up to a 2.0 times and on average a 1.3 times improvement in serving throughput, reduces the average inference latency by 1.5 times compared with state-of-the-art systems given the same price budget, and achieves comparable inference performance with a 30% lower price budget.
Key facts. Cited by 20 papers in the map (data through 7 Oct 2026). First posted on arXiv 11 Feb 2025.
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Citing papers per year: 2025: 8; 2026: 12.
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- 2025Taming the Titans: A Survey of Efficient LLM Inference Servingcited by 16
- 2025Parallax: Efficient LLM Inference Service over Decentralized Environmentcited by 12
- 2025UCCL-EP: Portable Expert-Parallel Communicationcited by 11
- 2025Beyond the Buzz: A Pragmatic Take on Inference Disaggregationcited by 9
- 2025AReaL-Hex: Accommodating Asynchronous RL Training over Heterogeneous GPUscited by 8
- 2025FSA: An Alternative Efficient Implementation of Native Sparse Attention Kernelcited by 7
- 2026BOute: Cost-Efficient LLM Serving with Heterogeneous LLMs and GPUs via Multi-Objective Bayesian Optimizationcited by 6
- 2025Cascadia: An Efficient Cascade Serving System for Large Language Modelscited by 5
- 2025Disaggregated Prefill and Decoding Inference System for Large Language Model Serving on Multi-Vendor GPUscited by 3
- 2026Rethinking Data Curation in LLM Training: Online Reweighting Offers Better Generalization than Offline Methodscited by 3
- 2026OServe: Accelerating LLM Serving via Spatial-Temporal Workload Orchestrationcited by 2
- 2026Observation, Not Prediction: Conversation-Level Disaggregated Scheduling for Agentic Servingcited by 2
8 more
- 2026TIDE: Temporal Incremental Draft Engine for Self-Improving LLM Inferencecited by 1
- 2026Autopoiesis: A Self-Evolving System Paradigm for LLM Serving Under Runtime Dynamicscited by 1
- 2026RouteBalance: Fused Model Routing and Load Balancing for Heterogeneous LLM Servingcited by 1
- 2026Trust-Aware Routing for Distributed Generative AI Inference at the Edgecited by 0
- 2026Tessera: Unlocking Heterogeneous GPUs through Kernel-Granularity Disaggregationcited by 0
- 2026HexAGenT: Efficient Agentic LLM Serving via Workflow- and Heterogeneity-Aware Schedulingcited by 0
- 2026E2LLM: Towards Efficient LLM Serving in Heterogeneous Edge/Fog Environmentscited by 0
- 2026OpWeave: Flexible Operator Disaggregation for Heterogeneous LLM Servingcited by 0
- 2026OpWeave: Flexible Operator Disaggregation for Heterogeneous LLM Serving13 Sep 2026
- 2026RouteBalance: Fused Model Routing and Load Balancing for Heterogeneous LLM Serving16 Jun 2026
- 2026E2LLM: Towards Efficient LLM Serving in Heterogeneous Edge/Fog Environments2 Jun 2026
- 2026Observation, Not Prediction: Conversation-Level Disaggregated Scheduling for Agentic Serving1 Jun 2026
- 2026HexAGenT: Efficient Agentic LLM Serving via Workflow- and Heterogeneity-Aware Scheduling15 May 2026
- 2026Rethinking Data Curation in LLM Training: Online Reweighting Offers Better Generalization than Offline Methods19 Apr 2026
- 2026Tessera: Unlocking Heterogeneous GPUs through Kernel-Granularity Disaggregation11 Apr 2026
- 2026Autopoiesis: A Self-Evolving System Paradigm for LLM Serving Under Runtime Dynamics8 Apr 2026
- 2026Trust-Aware Routing for Distributed Generative AI Inference at the Edge30 Mar 2026
- 2026OServe: Accelerating LLM Serving via Spatial-Temporal Workload Orchestration12 Feb 2026
- 2026BOute: Cost-Efficient LLM Serving with Heterogeneous LLMs and GPUs via Multi-Objective Bayesian Optimization11 Feb 2026
- 2026TIDE: Temporal Incremental Draft Engine for Self-Improving LLM Inference5 Feb 2026
8 more
- 2025UCCL-EP: Portable Expert-Parallel Communication22 Dec 2025
- 2025AReaL-Hex: Accommodating Asynchronous RL Training over Heterogeneous GPUs2 Nov 2025
- 2025Parallax: Efficient LLM Inference Service over Decentralized Environment30 Sep 2025
- 2025Disaggregated Prefill and Decoding Inference System for Large Language Model Serving on Multi-Vendor GPUs22 Sep 2025
- 2025FSA: An Alternative Efficient Implementation of Native Sparse Attention Kernel25 Aug 2025
- 2025Beyond the Buzz: A Pragmatic Take on Inference Disaggregation5 Jun 2025
- 2025Cascadia: An Efficient Cascade Serving System for Large Language Models4 Jun 2025
- 2025Taming the Titans: A Survey of Efficient LLM Inference Serving28 Apr 2025
- 2025Taming the Titans: A Survey of Efficient LLM Inference Servingcited by 16
- 2025Parallax: Efficient LLM Inference Service over Decentralized Environmentcited by 12
- 2026BOute: Cost-Efficient LLM Serving with Heterogeneous LLMs and GPUs via Multi-Objective Bayesian Optimizationcited by 6
- 2025Cascadia: An Efficient Cascade Serving System for Large Language Modelscited by 5
- 2025Disaggregated Prefill and Decoding Inference System for Large Language Model Serving on Multi-Vendor GPUscited by 3
- 2026OServe: Accelerating LLM Serving via Spatial-Temporal Workload Orchestrationcited by 2
- 2026Autopoiesis: A Self-Evolving System Paradigm for LLM Serving Under Runtime Dynamicscited by 1
- 2026RouteBalance: Fused Model Routing and Load Balancing for Heterogeneous LLM Servingcited by 1
- 2026HexAGenT: Efficient Agentic LLM Serving via Workflow- and Heterogeneity-Aware Schedulingcited by 0
- 2026E2LLM: Towards Efficient LLM Serving in Heterogeneous Edge/Fog Environmentscited by 0
- 2026RouteBalance: Fused Model Routing and Load Balancing for Heterogeneous LLM Serving16 Jun 2026
- 2026E2LLM: Towards Efficient LLM Serving in Heterogeneous Edge/Fog Environments2 Jun 2026
- 2026HexAGenT: Efficient Agentic LLM Serving via Workflow- and Heterogeneity-Aware Scheduling15 May 2026
- 2026Autopoiesis: A Self-Evolving System Paradigm for LLM Serving Under Runtime Dynamics8 Apr 2026
- 2026OServe: Accelerating LLM Serving via Spatial-Temporal Workload Orchestration12 Feb 2026
- 2026BOute: Cost-Efficient LLM Serving with Heterogeneous LLMs and GPUs via Multi-Objective Bayesian Optimization11 Feb 2026
- 2025Parallax: Efficient LLM Inference Service over Decentralized Environment30 Sep 2025
- 2025Disaggregated Prefill and Decoding Inference System for Large Language Model Serving on Multi-Vendor GPUs22 Sep 2025
- 2025Cascadia: An Efficient Cascade Serving System for Large Language Models4 Jun 2025
- 2025Taming the Titans: A Survey of Efficient LLM Inference Serving28 Apr 2025
- 2026OpWeave: Flexible Operator Disaggregation for Heterogeneous LLM Serving13 Sep 2026
- 2025UCCL-EP: Portable Expert-Parallel Communication22 Dec 2025
- 2025Beyond the Buzz: A Pragmatic Take on Inference Disaggregationcited by 9
- 2025AReaL-Hex: Accommodating Asynchronous RL Training over Heterogeneous GPUscited by 8
- 2025FSA: An Alternative Efficient Implementation of Native Sparse Attention Kernelcited by 7
- 2026Trust-Aware Routing for Distributed Generative AI Inference at the Edgecited by 0
- 2026Tessera: Unlocking Heterogeneous GPUs through Kernel-Granularity Disaggregationcited by 0
- 2026Tessera: Unlocking Heterogeneous GPUs through Kernel-Granularity Disaggregation11 Apr 2026
- 2026Trust-Aware Routing for Distributed Generative AI Inference at the Edge30 Mar 2026
- 2025AReaL-Hex: Accommodating Asynchronous RL Training over Heterogeneous GPUs2 Nov 2025
- 2025FSA: An Alternative Efficient Implementation of Native Sparse Attention Kernel25 Aug 2025
- 2025Beyond the Buzz: A Pragmatic Take on Inference Disaggregation5 Jun 2025
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