Panacea: Mitigating Harmful Fine-tuning for Large Language Models via Post-fine-tuning Perturbation
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Abstract (arXiv)
Harmful fine-tuning attack introduces significant security risks to the fine-tuning services. Main-stream defenses aim to vaccinate the model such that the later harmful fine-tuning attack is less effective. However, our evaluation results show that such defenses are fragile--with a few fine-tuning steps, the model still can learn the harmful knowledge. To this end, we do further experiment and find that an embarrassingly simple solution--adding purely random perturbations to the fine-tuned model, can recover the model from harmful behaviors, though it leads to a degradation in the model's fine-tuning performance. To address the degradation of fine-tuning performance, we further propose Panacea, which optimizes an adaptive perturbation that will be applied to the model after fine-tuning. Panacea maintains model's safety alignment performance without compromising downstream fine-tuning performance. Comprehensive experiments are conducted on different harmful ratios, fine-tuning tasks and mainstream LLMs, where the average harmful scores are reduced by up-to 21.2%, while maintaining fine-tuning performance. As a by-product, we analyze the adaptive perturbation and show that different layers in various LLMs have distinct safety affinity, which coincide with finding from several previous study. Source code available at https://github.com/w-yibo/Panacea.
Key facts. Cited by 20 papers in the map (data through 7 Oct 2026). Builds on 65 of its 146 references that are in the map. First posted on arXiv 30 Jan 2025.
Builds on
65 of 146 references.
References · 65
- 2022Training language models to follow instructions with human feedbackcited by 15,712
- 2021LoRA: Low-Rank Adaptation of Large Language Modelscited by 14,084
- 2023Llama 2: Open Foundation and Fine-Tuned Chat Modelscited by 12,865
- 2021Training Verifiers to Solve Math Word Problemscited by 9,743
- 2023Direct Preference Optimization: Your Language Model is Secretly a Reward Modelcited by 7,916
- 2022Training a Helpful and Harmless Assistant with Reinforcement Learning from Human Feedbackcited by 3,634
- 2023Universal and Transferable Adversarial Attacks on Aligned Language Modelscited by 2,914
- 2015Character-level Convolutional Networks for Text Classificationcited by 2,293
- 2024Qwen2 Technical Reportcited by 2,076
- 2024Gemma 2: Improving Open Language Models at a Practical Sizecited by 1,928
- 2017Decoupled Weight Decay Regularizationcited by 1,722
- 2023Fine-tuning Aligned Language Models Compromises Safety, Even When Users Do Not Intend To!cited by 1,106
38 more
- 2023BeaverTails: Towards Improved Safety Alignment of LLM via a Human-Preference Datasetcited by 828
- 2023RAFT: Reward rAnked FineTuning for Generative Foundation Model Alignmentcited by 672
- 2023RRHF: Rank Responses to Align Language Models with Human Feedback without tearscited by 454
- 2024Safety Alignment Should Be Made More Than Just a Few Tokens Deepcited by 450
- 2023Safety-Tuned LLaMAs: Lessons From Improving the Safety of Large Language Models that Follow Instructionscited by 377
- 2023Shadow Alignment: The Ease of Subverting Safely-Aligned Language Modelscited by 284
- 2024SORRY-Bench: Systematically Evaluating Large Language Model Safety Refusalcited by 224
- 2024Assessing the Brittleness of Safety Alignment via Pruning and Low-Rank Modificationscited by 220
- 2023LoRA Fine-tuning Efficiently Undoes Safety Training in Llama 2-Chat 70Bcited by 183
- 2023Removing RLHF Protections in GPT-4 via Fine-Tuningcited by 165
- 2024Safety Fine-Tuning at (Almost) No Cost: A Baseline for Vision Large Language Modelscited by 160
- 2024Latent Adversarial Training Improves Robustness to Persistent Harmful Behaviors in LLMscited by 158
- 2023Chain of Hindsight Aligns Language Models with Feedbackcited by 147
- 2024Tamper-Resistant Safeguards for Open-Weight LLMscited by 132
- 2024Safety Layers in Aligned Large Language Models: The Key to LLM Securitycited by 126
- 2024Safe LoRA: the Silver Lining of Reducing Safety Risks when Fine-tuning Large Language Modelscited by 122
- 2024What is in Your Safe Data? Identifying Benign Data that Breaks Safetycited by 114
- 2024Vaccine: Perturbation-aware Alignment for Large Language Models against Harmful Fine-tuning Attackcited by 113
- 2024Keeping LLMs Aligned After Fine-tuning: The Crucial Role of Prompt Templatescited by 94
- 2023Fine-tuning can cripple your foundation model; preserving features may be the solutioncited by 92
- 2024Booster: Tackling Harmful Fine-tuning for Large Language Models via Attenuating Harmful Perturbationcited by 92
- 2024Harmful Fine-tuning Attacks and Defenses for Large Language Models: A Surveycited by 86
- 2024Defending Against Unforeseen Failure Modes with Latent Adversarial Trainingcited by 82
- 2024Covert Malicious Finetuning: Challenges in Safeguarding LLM Adaptationcited by 74
- 2024Antidote: Post-fine-tuning Safety Alignment for Large Language Models against Harmful Fine-tuningcited by 71
- 2024SEAL: Safety-enhanced Aligned LLM Fine-tuning via Bilevel Data Selectioncited by 64
- 2023Pairwise Proximal Policy Optimization: Harnessing Relative Feedback for LLM Alignmentcited by 57
- 2024On Evaluating the Durability of Safeguards for Open-Weight LLMscited by 51
- 2021RDA: Robust Domain Adaptation via Fourier Adversarial Attackingcited by 48
- 2024Navigating the Safety Landscape: Measuring Risks in Finetuning Large Language Modelscited by 45
- 2024A safety realignment framework via subspace-oriented model fusion for large language modelscited by 40
- 2025SaLoRA: Safety-Alignment Preserved Low-Rank Adaptationcited by 39
- 2024NLSR: Neuron-Level Safety Realignment of Large Language Models Against Harmful Fine-Tuningcited by 37
- 2024Targeted Vaccine: Safety Alignment for Large Language Models against Harmful Fine-Tuning via Layer-wise Perturbationcited by 35
- 2024Immunization against harmful fine-tuning attackscited by 33
- 2024Safety-Aware Fine-Tuning of Large Language Modelscited by 33
- 2024Towards Understanding the Fragility of Multilingual LLMs against Fine-Tuning Attackscited by 33
- 2024No Two Devils Alike: Unveiling Distinct Mechanisms of Fine-tuning Attackscited by 28
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Citing papers per year: 2025: 12; 2026: 8.
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- 2025A Comprehensive Survey in LLM(-Agent) Full Stack Safety: Data, Training and Deploymentcited by 110
- 2025Safety at Scale: A Comprehensive Survey of Large Model and Agent Safetycited by 63
- 2025Backdoor Cleaning without External Guidance in MLLM Fine-tuningcited by 34
- 2025Benign Samples Matter! Fine-tuning On Outlier Benign Samples Severely Breaks Safetycited by 22
- 2025Adaptive Defense against Harmful Fine-Tuning for Large Language Models via Bayesian Data Schedulercited by 12
- 2025CTRAP: Embedding Collapse Trap to Safeguard Large Language Models from Harmful Fine-Tuningcited by 11
- 2025Shape it Up! Restoring LLM Safety during Finetuningcited by 11
- 2025Towards Resilient Safety-driven Unlearning for Diffusion Models against Downstream Fine-tuningcited by 8
- 2025Safety Subspaces are Not Linearly Distinct: A Fine-Tuning Case Studycited by 6
- 2025Pharmacist: Safety Alignment Data Curation for Large Language Models against Harmful Fine-tuningcited by 6
- 2026Antibody: Strengthening Defense Against Harmful Fine-Tuning for Large Language Models via Attenuating Harmful Gradient Influencecited by 6
- 2025Reshaping Representation Space to Balance the Safety and Over-rejection in Large Audio Language Modelscited by 4
8 more
- 2026Q-realign: Piggybacking Realignment on Quantization for Safe and Efficient LLM Deploymentcited by 4
- 2026Surgery: Mitigating Harmful Fine-Tuning for Large Language Models via Attention Sinkcited by 3
- 2025Safety-Aligned Weights Are Not Enough: Refusal-Teacher-Guided Finetuning Enhances Safety and Downstream Performance under Harmful Finetuning Attackscited by 2
- 2026Safeguarding LLM Fine-tuning via Push-Pull Distributional Alignmentcited by 2
- 2026Preventing Safety Drift in Large Language Models via Coupled Weight and Activation Constraintscited by 2
- 2026Safety Anchor: Defending Harmful Fine-tuning via Geometric Bottleneckscited by 0
- 2026Jailbreak to Protect: Buffering and Reinforcing via Temporary Jailbreaking for Safe Fine-Tuning in Large Language Modelscited by 0
- 2026The Safeguard Worked. Is the LLM System Safer?cited by 0
- 2026The Safeguard Worked. Is the LLM System Safer?1 Sep 2026
- 2026Jailbreak to Protect: Buffering and Reinforcing via Temporary Jailbreaking for Safe Fine-Tuning in Large Language Models23 May 2026
- 2026Safety Anchor: Defending Harmful Fine-tuning via Geometric Bottlenecks7 May 2026
- 2026Preventing Safety Drift in Large Language Models via Coupled Weight and Activation Constraints14 Apr 2026
- 2026Antibody: Strengthening Defense Against Harmful Fine-Tuning for Large Language Models via Attenuating Harmful Gradient Influence28 Feb 2026
- 2026Surgery: Mitigating Harmful Fine-Tuning for Large Language Models via Attention Sink5 Feb 2026
- 2026Q-realign: Piggybacking Realignment on Quantization for Safe and Efficient LLM Deployment13 Jan 2026
- 2026Safeguarding LLM Fine-tuning via Push-Pull Distributional Alignment12 Jan 2026
- 2025Adaptive Defense against Harmful Fine-Tuning for Large Language Models via Bayesian Data Scheduler31 Oct 2025
- 2025Pharmacist: Safety Alignment Data Curation for Large Language Models against Harmful Fine-tuning11 Oct 2025
- 2025Towards Resilient Safety-driven Unlearning for Diffusion Models against Downstream Fine-tuning22 Jul 2025
- 2025Safety-Aligned Weights Are Not Enough: Refusal-Teacher-Guided Finetuning Enhances Safety and Downstream Performance under Harmful Finetuning Attacks9 Jun 2025
8 more
- 2025Reshaping Representation Space to Balance the Safety and Over-rejection in Large Audio Language Models26 May 2025
- 2025Shape it Up! Restoring LLM Safety during Finetuning22 May 2025
- 2025Backdoor Cleaning without External Guidance in MLLM Fine-tuning22 May 2025
- 2025CTRAP: Embedding Collapse Trap to Safeguard Large Language Models from Harmful Fine-Tuning22 May 2025
- 2025Safety Subspaces are Not Linearly Distinct: A Fine-Tuning Case Study20 May 2025
- 2025Benign Samples Matter! Fine-tuning On Outlier Benign Samples Severely Breaks Safety11 May 2025
- 2025A Comprehensive Survey in LLM(-Agent) Full Stack Safety: Data, Training and Deployment22 Apr 2025
- 2025Safety at Scale: A Comprehensive Survey of Large Model and Agent Safety2 Feb 2025
- 2025Shape it Up! Restoring LLM Safety during Finetuningcited by 11
- 2025Safety Subspaces are Not Linearly Distinct: A Fine-Tuning Case Studycited by 6
- 2025Pharmacist: Safety Alignment Data Curation for Large Language Models against Harmful Fine-tuningcited by 6
- 2026Surgery: Mitigating Harmful Fine-Tuning for Large Language Models via Attention Sinkcited by 3
- 2026Safeguarding LLM Fine-tuning via Push-Pull Distributional Alignmentcited by 2
- 2026Preventing Safety Drift in Large Language Models via Coupled Weight and Activation Constraintscited by 2
- 2026Safety Anchor: Defending Harmful Fine-tuning via Geometric Bottleneckscited by 0
- 2026Safety Anchor: Defending Harmful Fine-tuning via Geometric Bottlenecks7 May 2026
- 2026Preventing Safety Drift in Large Language Models via Coupled Weight and Activation Constraints14 Apr 2026
- 2026Surgery: Mitigating Harmful Fine-Tuning for Large Language Models via Attention Sink5 Feb 2026
- 2026Safeguarding LLM Fine-tuning via Push-Pull Distributional Alignment12 Jan 2026
- 2025Pharmacist: Safety Alignment Data Curation for Large Language Models against Harmful Fine-tuning11 Oct 2025
- 2025Shape it Up! Restoring LLM Safety during Finetuning22 May 2025
- 2025Safety Subspaces are Not Linearly Distinct: A Fine-Tuning Case Study20 May 2025
- 2025Benign Samples Matter! Fine-tuning On Outlier Benign Samples Severely Breaks Safetycited by 22
- 2025CTRAP: Embedding Collapse Trap to Safeguard Large Language Models from Harmful Fine-Tuningcited by 11
- 2026Antibody: Strengthening Defense Against Harmful Fine-Tuning for Large Language Models via Attenuating Harmful Gradient Influencecited by 6
- 2026Q-realign: Piggybacking Realignment on Quantization for Safe and Efficient LLM Deploymentcited by 4
- 2025Safety-Aligned Weights Are Not Enough: Refusal-Teacher-Guided Finetuning Enhances Safety and Downstream Performance under Harmful Finetuning Attackscited by 2
- 2026Jailbreak to Protect: Buffering and Reinforcing via Temporary Jailbreaking for Safe Fine-Tuning in Large Language Modelscited by 0
- 2026Jailbreak to Protect: Buffering and Reinforcing via Temporary Jailbreaking for Safe Fine-Tuning in Large Language Models23 May 2026
- 2026Antibody: Strengthening Defense Against Harmful Fine-Tuning for Large Language Models via Attenuating Harmful Gradient Influence28 Feb 2026
- 2026Q-realign: Piggybacking Realignment on Quantization for Safe and Efficient LLM Deployment13 Jan 2026
- 2025Safety-Aligned Weights Are Not Enough: Refusal-Teacher-Guided Finetuning Enhances Safety and Downstream Performance under Harmful Finetuning Attacks9 Jun 2025
- 2025CTRAP: Embedding Collapse Trap to Safeguard Large Language Models from Harmful Fine-Tuning22 May 2025
- 2025Benign Samples Matter! Fine-tuning On Outlier Benign Samples Severely Breaks Safety11 May 2025
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