Enhancing In-Hospital Mortality Prediction Using Multi-Representational Learning with LLM-Generated Expert Summaries
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Abstract (arXiv)
To evaluate a multi-representational framework in which large language model (LLM)-generated expert summaries of intensive care unit (ICU) notes are fused with physiology for in-hospital mortality (IHM) prediction, and to determine how much of the resulting gain is non-redundant with the notes themselves. Using MIMIC-III (19,211 first ICU stays, 12.83% mortality), we encoded 48-hour physiology, clinical notes, and LLM summaries generated under a prompt forbidding prognostication, then fused them. Redundancy was assessed by ridge recoverability, linear probes, and retrained ablations substituting a note-orthogonal residual or a patient-shuffled summary embedding. On 3,843 held-out stays, fusion reached AUPRC 0.4977/AUROC 0.8429 versus 0.3625/0.7770 for physiology alone. Ridge regression from note embeddings explained 40.8% of summary-embedding variance. The note-orthogonal residual retained a minority of the gain (+0.0258 AUPRC, 95% CI 0.005--0.047; 28%), while patient-shuffled summaries fell below the reference. Summaries improve prediction patient-specifically, but predominantly by reorganizing information the notes already contain.
Key facts. Cited by 2 papers in the map (data through 13 Oct 2026). Builds on 6 of its 10 references that are in the map. First posted on arXiv 25 Nov 2024.
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References · 6
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